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CAMK2A / CaMKII Alpha
calcium/calmodulin-dependent protein kinase II alpha
CAMK2A / CaMKII Alpha belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
| Gene Name: | calcium/calmodulin-dependent protein kinase II alpha |
| Family/Subfamily: | Protein Kinase , CAMK2 |
| Synonyms: | CAMK2A, AlphaCaMKII, CaM-kinase II alpha chain, CaMK-II subunit alpha, CAMKA, CaM kinase II alpha, CaMK II alpha, CaMK-II alpha subunit, CaMKIINalpha, CaM kinase II alpha subunit, CaM kinase II subunit alpha, CaMKII alpha, CaMKIIalpha, KIAA0968 |
| Target Sequences: | NM_015981 NP_057065.2 Q9UQM7 |
Publications (4)
1
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Cardin JA, Carln M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Nature. 2009 459:663-7. (IHC)
[PubMed:19396156]
2
Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J, Rainnie DG. Neuroscience. 2010 171:721-33. (IHC-Fr; Rat)
[Full Text Article]
[PubMed:20849929]
[PMC:PMC2987400]
3
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder. Shanshan Zhu, Zachary A Cordner, Jiali Xiong, Chi-Tso Chiu, Arabiye Artola, Yanning Zuo, Andrew D Nelson, Tae-Yeon Kim, Natalya Zaika, Brian M Woolums, Evan J Hess, Xiaofang Wang, De-Maw Chuang, Mikhail M Pletnikov, Paul M Jenkins, Kellie L Tamashiro, Christopher A Ross. Proceedings of the National Academy of Sciences of the United States of America. 2017 September;114:10479-10484. [Full Text Article]
[PubMed:28894008]
[PMC:PMC5625892]
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Neuroscience
CAMK2A / CaMKII Alpha Goat anti-Human Polyclonal (aa455-468) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Neuroscience
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Rat, Orangutan, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal Antibody
Mouse, Bovine, Rat
ELISA, IF, IHC, IP, RIA, WB
Unconjugated
25 µg/$483; 100 µg/$688
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$890
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,104
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,104
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,104
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,104
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (PE) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,104
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (pThr286) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (pThr305) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2A / CaMKII Alpha Mouse anti-Mouse Monoclonal (aa281-294) Antibody
Mouse, Rat
ELISA, ICC, IP, WB
Unconjugated
100 µl/$875
![CAMK2A / CaMKII Alpha Antibody - Immunofluorescence of monoclonal antibody to CAMK2A on HeLa cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/camk2a-camkii-alpha-antibody-clone-2c4-ls-c196810/144136_5103147.jpg)
CAMK2A / CaMKII Alpha Mouse anti-Human Monoclonal (2C4) Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$423
CAMK2A / CaMKII Alpha Mouse anti-Mouse Monoclonal (6G9) Antibody
Mouse, Bovine, Rat
IHC, RIA, WB
Unconjugated
100 µg/$531
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa344-371) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CAMK2A / CaMKII Alpha Mouse anti-Mouse Monoclonal (aa281-294) (22B1) Antibody
Mouse, Rat
IF, WB
Unconjugated
100 µg/$531
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal Antibody
Bovine, Rat
ELISA, IHC, WB
Unconjugated
100 µg/$884
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