CAMK2A (calcium/calmodulin-dependent protein kinase II alpha) belongs to the Ca(2+)/calmodulin-dependent protein kinase family, and it is involved in plasticity at glutamatergic synapses, hippocampal long-term potentiation and spatial learning. CAMK2A mutations have been associated with autism spectrum disorder (ASD), impaired physical and intellectual development, and seizures. For example, expressed E183V-mutant CAMK2A protein has reduced targeting of dendritic spines, which causes a reduction in density and excitatory synaptic transmission. This is associated with the behavioral changes seen in ASD including repetitive behavior and impaired social interaction. In immunohistochemistry, CAMK2A is cytoplasmic and membranous positivity in neurons, the adrenal gland, the lung, the liver, the pancreas, the gastrointestinal tract, the kidney, reproductive tissues, and immune tissues. References: Nat Rev Neurosci. 2012 Feb 15;13(3):169-82, PMID: 22334212; J Neurosci. 2017 Feb 22; 37(8): 2216–2233; Elife. 2018 May 22;7. pii: e32451, PMID: 29784083