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AURKA / Aurora-A
aurora kinase A
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
| Gene Name: | aurora kinase A |
| Family/Subfamily: | Protein Kinase , Aurora/IPL1-like |
| Synonyms: | AURKA, AIK, AIRK1, ARK1, Aurora-A kinase, Aurora kinase A, Aurora/IPL1-like kinase, AYK1, AURA, AURORA2, Breast tumor-amplified kinase, Breast-tumor-amplified kinase, BTAK, HARK1, IPL1-related kinase, Serine/threonine kinase 6, STK7, STK6, PPP1R47, ARK-1, Aurora 2, Aurora-A, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, IAK1, Serine/threonine kinase 15, STK15 |
| Target Sequences: | NM_003600 NP_003591.2 O14965 |
Publications (3)
1
Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor. Fung TK, Ma HT, Poon RY. Molecular biology of the cell. 2007 18:1861-73.
[PubMed:17344473]
[PMC:PMC1855023]
2
Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A. Liu HS, Ke CS, Cheng HC, Huang CY, Su CL. Molecular pharmacology. 2011 80:638-46.
[PubMed:21757545]
3
Expression of aurora kinase A and B in chondrosarcoma and its relationship with the prognosis. Liang X, Wang D, Wang Y, Zhou Z, Zhang J, Li J. Diagnostic pathology. 2012 7:84.
[PubMed:22809428]
[PMC:PMC3487823]
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AURKA / Aurora-A Goat anti-Human Polyclonal (aa394-403) Antibody
Human
IHC, IHC-P, IP, Peptide-ELISA, WB
Unconjugated
50 µg/$485
AURKA / Aurora-A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
AURKA / Aurora-A Rabbit anti-Human Polyclonal (aa100-150) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
AURKA / Aurora-A Mouse anti-Human Monoclonal (aa268-404) (2D8A4) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
AURKA / Aurora-A Mouse anti-Human Monoclonal (N-Terminus) (35C1) Antibody
Human
IF, IP, WB
Unconjugated
0.1 mg/$395
AURKA / Aurora-A Mouse anti-Human Monoclonal (7A3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
AURKA / Aurora-A Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
AURKA / Aurora-A Rabbit anti-Human Polyclonal (280-360 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AURKA / Aurora-A Rabbit anti-Human Polyclonal (pThr288) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
AURKA / Aurora-A Rabbit anti-Human Polyclonal (230-310 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AURKA / Aurora-A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$332
AURKA / Aurora-A Mouse anti-Human Monoclonal (1F8) Antibody
Rat, Primate, Human
ELISA, Flo, ICC, IF, WB
Unconjugated
0.1 ml/$386
AURKA / Aurora-A Mouse anti-Human Monoclonal (1F8) Antibody
Rat, Non-Human Primate, Human
Flo, ICC, IF, WB
Unconjugated
100 µl/$541
AURKA / Aurora-A Mouse anti-Human Monoclonal Antibody
Rat, Human, Monkey
ELISA, Flo, IF, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
AURKA / Aurora-A Rabbit anti-Human Polyclonal (pThr288) Antibody
Mouse, Sheep, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
AURKA / Aurora-A Mouse anti-Human Monoclonal (1F8) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$459
AURKA / Aurora-A Rabbit anti-Human Polyclonal (aa1-131) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
AURKA / Aurora-A Rabbit anti-Human Polyclonal (pThr288) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
AURKA / Aurora-A Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
AURKA / Aurora-A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
AURKA / Aurora-A Mouse anti-Human Monoclonal (aa268-404) (4H5A8) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
![AURKA / Aurora-A Antibody - Immunofluorescence of monoclonal antibody to STK6 on HeLa cell. [antibody concentration 30 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/aurka-aurora-a-antibody-aa1-111-clone-5f8-ls-c133953/53400_5103530.jpg)
AURKA / Aurora-A Mouse anti-Human Monoclonal (aa1-111) (5F8) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
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