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ATXN2 / SCA2 / Ataxin-2

ataxin 2

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.

Gene Name: ataxin 2
Synonyms: ATXN2, ASL13, Ataxin 2, ATX2, Ataxin-2, SCA2, TNRC13
Target Sequences: NM_002973 NP_002964.3 Q99700

☰ Filters
Antibodies (26)
ELISA Kits (8)
Proteins (1)
Primary (26)
Recombinant (1)
Sandwich (8)
ATXN2 / SCA2 / Ataxin-2 (35)
Human (26)
Mouse (12)
Rat (9)
Bat (5)
Bovine (5)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (6)
Hamster (1)
Horse (5)
Monkey (6)
Pig (5)
Porcine (1)
Rabbit (1)
Sheep (2)
IHC (9)
IHC-P (4)
WB (21)
ELISA (7)
IF (5)
IP (3)
Peptide-ELISA (6)
rabbit (24)
goat (1)
rabbit-new zealand white (1)
Product Group
IHCPlus (1)
IgG (14)
polyclonal pc (26)
12 x 8-Well Microstrips (1)
96-Well Strip Plate (7)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (20)
C-Terminus (3)
700-780 aa, Internal (1)
Internal (1)
Phe774 (1)
aa1262-1312 (1)
aa1283-1313 (1)
aa1293-1313 (1)
aa321-355 (1)
aa479-489 (1)
aa721-780 (1)
aa725-757 (1)
aa725-774 (1)
aa731-780 (1)
No (35)
Plasma (4)
Serum (4)
GST, N-terminus (1)
Human (1)
Wheat Germ Extract (1)
ATXN2 / SCA2 / Ataxin-2 Antibody - Immunofluorescent analysis of HepG2 cells using ATXN2 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
ATXN2 / SCA2 / Ataxin-2 Antibody - Western blot analysis of the lysates from HepG2 cells using ATXN2 antibody.
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (aa725-774) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ATXN2 / SCA2 / Ataxin-2 Antibody - Goat Anti-ATXN2 Antibody Immunofluorescence analysis of paraformaldehyde fixed A431 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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ATXN2 / SCA2 / Ataxin-2 Goat anti-Human Polyclonal (aa479-489) Antibody
IF, IHC, Peptide-ELISA
Unconjugated
100 µg/$503
ATXN2 / SCA2 / Ataxin-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
ATXN2 / SCA2 / Ataxin-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ATXN2 / SCA2 / Ataxin-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
ATXN2 / SCA2 / Ataxin-2 ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATXN2 / SCA2 / Ataxin-2 Antibody - Immunohistochemical analysis of Ataxin 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
ATXN2 / SCA2 / Ataxin-2 Antibody - Western blot of Ataxin-2 antibody
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (700-780 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ATXN2 / SCA2 / Ataxin-2 Antibody - Detection of Human and Mouse ATX2/SCA2 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, and mouse TCMK-1 cells. Antibodies: Affinity purified rabbit anti-ATX2/SCA2 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (aa1262-1312) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ATXN2 / SCA2 / Ataxin-2 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (aa721-780) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
ATXN2 / SCA2 / Ataxin-2 Antibody - ATXN2 / Ataxin-2 antibody Western blot of PANC1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
ATXN2 / SCA2 / Ataxin-2 Antibody - ATXN2 / Ataxin-2 antibody Western blot of PANC1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
ATXN2 / SCA2 / Ataxin-2 Antibody - Immunohistochemistry of paraffin-embedded Rat brain using ATXN2 Polyclonal Antibody at dilution of 1:100 (40x lens).
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ATXN2 / SCA2 / Ataxin-2 Antibody - ATX2 antibody IHC-paraffin. IHC(P): Mouse Brain Tissue.
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ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (aa1283-1313) Antibody
Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ATXN2 / SCA2 / Ataxin-2 Antibody
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
ATXN2 / SCA2 / Ataxin-2 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$393
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (Phe774) Antibody
Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
ATXN2 / SCA2 / Ataxin-2 Antibody - IHC analysis of ATX2 using anti-ATX2 antibody. ATX2 was detected in immunocytochemical section of A549 cell. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml rabbit anti-ATX2 Antibody overnight at 4°C. DyLight®488 Conjugated Avidin was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (aa1293-1313) Antibody
Mouse, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
ATXN2 / SCA2 / Ataxin-2 Antibody - Western blot analysis of extracts from HepG2 cells, Jurkat cells and 293 cells, using ATXN2 antibody.
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
ATXN2 / SCA2 / Ataxin-2 Antibody - All lanes: Anti-ATXN2 Antibody (N-Term) at 1:2000 dilution. Lane 1: human brain lysate. Lane 2: mouse brain lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 140 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Select
ATXN2 / SCA2 / Ataxin-2 Rabbit anti-Human Polyclonal (aa321-355) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
Viewing 1-25 of 35 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).