ANGPT1 / Angiopoietin-1

angiopoietin 1

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

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Antibodies (127)

ELISA Kits (36)

Proteins (19)

Type

Competitive EIA (2)

Custom (4)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (2)

Primary (127)

Recombinant (16)

Sandwich (29)

Sandwich CLIA (1)

Target

ANGPT1 / Angiopoietin-1 (182)

Reactivity

Human (96)

Mouse (74)

Rat (44)

Bat (3)

Bovine (8)

Chicken (3)

Chimpanzee (6)

Dog (23)

Gibbon (6)

Horse (4)

Monkey (4)

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IP (3)

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Host

rabbit (103)

mouse (23)

goat (1)

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IHCPlus (4)

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IgG (27)

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Clonality

monoclonal mc (23)

polyclonal pc (104)

Clone

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aa21-228 (8)

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Internal (1)

aa158-207 (1)

aa16-350 (1)

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Yes (3)

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Cell Culture Supernatants (12)

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Fc, N-terminus (1)

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Purified (4)

Supernatant (1)

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Low endotoxin level (3)

Biologically Active

Biologically active (1)

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IHC-plus™ ANGPT1 / Angiopoietin-1 Antibody (aa15-45) LS-B62

(5.0) Rating

(1) Publication(s)

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Mouse Polyclonal (aa15-45) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$515

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IHC-plus™ ANGPT1 / Angiopoietin-1 Antibody (aa76-85) LS-B6867

(4.0) Rating

Antibody:

ANGPT1 / Angiopoietin-1 Goat anti-Human Polyclonal (aa76-85) Antibody

Reactivity:

Rabbit, Mouse, Dog, Horse, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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ANGPT1 / Angiopoietin-1 Antibody (aa360-409) LS-C151507

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Mouse Polyclonal (aa360-409) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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ANGPT1 / Angiopoietin-1 Antibody LS-C663529

Antibody:

ANGPT1 / Angiopoietin-1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$292; 200 µl/$327; 500 µl/$443; 1 ml/$501; 2 ml/$626; 5 ml/$1,072

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F2956

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$632

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Rat ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F10827

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

6.25 - 400 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$585

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F13065

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F5441

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant Fc, N-terminus) - LS-G146488

Source:

Human

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.9 kDa

Price:

10 µg/$317; 50 µg/$529

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F21304

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$528

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa16-498) - LS-G21689

Source:

E. coli

Tag:

His

Molecular Weight:

60 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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ANGPT1 / Angiopoietin-1 Antibody (aa304-450) LS-C292803

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Rat Polyclonal (aa304-450) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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ANGPT1 / Angiopoietin-1 Antibody (Internal) LS-C368576

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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ANGPT1 / Angiopoietin-1 Antibody (N-Terminus) LS-C137047

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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ANGPT1 / Angiopoietin-1 Antibody (aa284-452) LS-C292802

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (aa284-452) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$275; 200 µl/$303; 500 µl/$396; 1 ml/$443; 2 ml/$535; 5 ml/$907

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ANGPT1 / Angiopoietin-1 Antibody (aa284-452, Biotin) LS-C299370

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (aa284-452) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$282; 200 µl/$313; 500 µl/$415; 1 ml/$466; 2 ml/$568; 5 ml/$975

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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ANGPT1 / Angiopoietin-1 Antibody (Biotin) LS-C683707

Antibody:

ANGPT1 / Angiopoietin-1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$300; 200 µl/$338; 500 µl/$466; 1 ml/$530; 2 ml/$688; 5 ml/$1,149

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ANGPT1 / Angiopoietin-1 Antibody (PE) LS-C720049

Antibody:

ANGPT1 / Angiopoietin-1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$373; 200 µl/$443; 500 µl/$715; 1 ml/$873; 2 ml/$1,124; 5 ml/$2,031

• Biotin
• PE

• Biotin
• PE

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IHC-plus™ ANGPT1 / Angiopoietin-1 Antibody (aa158-207) LS-B13444

(4.0) Rating

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (aa158-207) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$515

Select

Rat ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F5442

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$715

Select

Human ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F3958

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.234 - 15 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$610

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IHC-plus™ ANGPT1 / Angiopoietin-1 Antibody (aa176-224) LS-B10907

(4.0) Rating

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (aa176-224) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

ANGPT1 / Angiopoietin-1 Antibody LS-C662031

Antibody:

ANGPT1 / Angiopoietin-1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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ANGPT1 / Angiopoietin-1 Antibody (aa374-402, FITC) LS-C251294

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (aa374-402) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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ANGPT1 / Angiopoietin-1 Antibody (aa374-402, Azide-free, HRP) LS-C251296

Antibody:

ANGPT1 / Angiopoietin-1 Rabbit anti-Human Polyclonal (aa374-402) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• FITC
• HRP, Azide-free

• FITC
• HRP, Azide-free

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