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AIFM1 / AIF / PDCD8
Apoptosis-inducing Factor, Mitochondrion-associated, 1
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.
| Gene Name: | Apoptosis-inducing Factor, Mitochondrion-associated, 1 |
| Family/Subfamily: | Apoptosis , not assigned-Apoptosis |
| Synonyms: | AIFM1, AIF, COXPD6, PDCD8, Programmed cell death 8 |
| Target Sequences: | NM_004208 NP_004199.1 O95831 |
Publications (2)
1
Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury. Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:9278-93. (WB)
[PubMed:17728442]
2
AIF inhibits tumor metastasis by protecting PTEN from oxidation. Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ. EMBO reports. 2015 16:1563-80. (WB; Human)
[Full Text Article]
[PubMed:26415504]
[PMC:PMC4641507]
Related Antibodies: LS-C147989.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa151-169) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
AIFM1 / AIF / PDCD8 Goat anti-Human Polyclonal Antibody
Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa70-98) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Sheep, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa211-260) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa211-260) (FITC) Antibody
Zebrafish, Pig, Horse, Mouse, Dog, Bovine, Rat, Hamster, Human, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (4E7) Antibody
Mouse, Rat, Human, Monkey
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal Antibody
Rat, Human, Monkey
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$575
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa582-613) Antibody
Rabbit, Mouse, Bovine, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$287; 100 µl/$431
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (4E7E11) Antibody
Mouse, Rat, Primate, Human
ICC, IF, WB
Unconjugated
100 µg/$541
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa596-613) Antibody
Rabbit, Mouse, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (AT22E9) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$688
AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (aa134-483) (OTI4E6) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µl/$434
AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (aa134-483) (Carrier-free) (OTI4E6) Antibody
Mouse, Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (Tyr85) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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