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A2M / Alpha-2-Macroglobulin
alpha-2-macroglobulin
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
| Gene Name: | alpha-2-macroglobulin |
| Synonyms: | A2M, CPAMD5, A2MD, FWP007, Alpha-2-M, Alpha-2-macroglobulin, S863-7 |
| Target Sequences: | NM_000014 NP_000005.2 P01023 |
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Antibodies
(155)
Type
Primary
(155)
Target
A2M / Alpha-2-Macroglobulin
(155)
Reactivity
Human
(81)
Mouse
(29)
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(42)
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(3)
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(2)
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(3)
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(3)
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(1)
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(10)
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(2)
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(2)
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(24)
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(9)
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(132)
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(50)
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(4)
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(6)
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(1)
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(9)
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(2)
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rabbit
(105)
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(27)
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(20)
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(7)
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(42)
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(5)
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(2)
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(2)
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(1)
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(17)
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(1)
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monoclonal mc
(27)
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(128)
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(1)
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(8)
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(10)
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(11)
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(2)
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(16)
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(10)
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(10)
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(17)
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(16)
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(3)
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(3)
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(12)
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(63)
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aa818-1048
(10)
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(8)
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(8)
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(8)
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(8)
aa574-734
(8)
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(8)
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(7)
aa93-120
(7)
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(5)
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(4)
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(2)
Internal
(2)
1100-1180 aa, C-terminal
(1)
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(1)
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(1)
Publications
No
(155)
A2M / Alpha-2-Macroglobulin Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
0.5 ml/$515
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
250 µg/$535
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Rabbit, Dog, Pig, Human
ELISA, IE, IHC, IHC-P, IP
Unconjugated
0.5 mg/$440
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (HRP) Antibody
Rabbit, Dog, Pig, Human
ELISA, IE
HRP Conjugated
100 µg/$611
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (Biotin) Antibody
Human
ICC, WB
Biotin Conjugated
50 µg/$1,042
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$866
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (aa417-430) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
10 ml/$508
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
A2M / Alpha-2-Macroglobulin Rabbit anti-Pig Polyclonal (aa1097-1357) Antibody
Pig
WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$303; 200 µl/$343; 500 µl/$475; 1 ml/$541; 2 ml/$712; 5 ml/$1,177
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal (F1-P1C11 #3) Antibody
Human
ELISA, IP, RIA, WB
Unconjugated
1 mg/$857
A2M / Alpha-2-Macroglobulin Mouse anti-Porcine Monoclonal (PSA24) Antibody
Porcine
IHC, IHC-Fr, IHC-P, WB
Unconjugated
200 µg/$672
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, ICC, IP, WB
Unconjugated
100 µg/$962
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (Lyophilized) Antibody
Human
ELISA, IHC, WB
Unconjugated, Lyophilized
100 µg/$567
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (Liquid) Antibody
Human
ELISA, IHC, WB
Unconjugated, Liquid
25 µl/$304
A2M / Alpha-2-Macroglobulin Mouse anti-Porcine Monoclonal (PAM-F101) Antibody
Porcine
IHC, IHC-Fr, WB
Unconjugated
200 µg/$617
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
2 ml/$1,225
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product results
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