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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
PLAP (alkaline phosphatase, placental type, ALPP) is an allosteric enzyme expressed in the placenta. PLAP is a membrane-bound protein that functions to catalyze phosphate monoester hydrolysis and transphosphorylation. In immunohistochemistry of cancer, PLAP is marker used to identify seminoma and malignant germ cell tumors (embryonal carcinoma and dysgerminoma), and it is also positive in ovarian, breast, lung, stomach, and pancreatic carcinomas. In normal tissues, PLAP stains placental trophoblasts.
References: J Phys Chem B. 2014 Dec 11;118(49):14302-13, PMID: 25409280; J Lab Med. 2004. 28 (2): 109–115, DOI:10.1515/labmed.2004.018; Clin. Biochem. 20 (6): 387–92, PMID: 3325192.