HSPD1 heat shock protein family D member 1 (HSP60) is a member of the mitochondrial chaperonin family that is required for the folding and assembly of proteins in the mitochondria. HSPD1 is also an interferon regulatory factor 3-interacting protein whose overexpression enhances activation of the IFN-beta promoter, contributing to the induction of the IFN-beta signaling pathway. Mutations in this gene cause some forms of hereditary spastic paraplegia. It is expressed in the adrenal, kidney, skeletal muscle, and many other tissues. References: Front Mol biosci 2016 3:49; PlosOne 2014 9(12):e114874; Science Direct 2002 70(5):1328