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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
HAVCR1 (KIM-1, TIM-1, CD365) is a member of the TIM family, with functional roles in asthma, transplant tolerance, allergic response and regulating immune cell activities. HAVCR1 is located on the surface of Type 2 helper T cells cells and is capable of activating T-cells and blocking peripheral tolerance. It is highly upregulated in injured kidneys. Additionally, it is a receptor for Hepatitis A virus, Ebola and Dengue virus. It is potentially a useful prognostic marker for renal cell, gastric and other cancers, where upregulation is correlated with progression and is linked to angiogenesis and proliferation during tumorigenesis. In immunohistochemistry of normal tissue, HAVCR1 has cytoplasmic and membranous positivity in glandular epithelia of various tissues, with prominent expression in the kidney and gastrointestinal tract.
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