CD207 (also called langerin) is a calcium-dependent lectin with binding specific for mannose. It is the major cell-surface receptor for Candida species, Saccharomyces species, and Malassezia furfur on Langerhans cells (dendritic cells of the epidermis and mucosa). It has been proposed that mannose binding leads to antigen internalization into cytoplasmic Birbeck granules in Langerhans cells, comprising a nonclassical antigen-processing pathway. CD207 is expressed in Langerhans cells. It is also expressed in gliomas (astrocytoma, malignant ependymoma) but not normal brain. Staining is used to identify Langerhans cells. References: Immunity. 2000;12(1):71-81. PMID: 10661407; Immunol Res. 2003;28(2):93-107. doi: 10.1385/IR:28:2:93; Mol Immunol. 2010;47(6):1216-1225. doi: 10.1016/j.molimm.2009.12.016; Cell Mol Immunol. 2017;14(4):360-370. doi: 10.1038/cmi.2015.87; J Biol Chem. 2010;285(9):6390-6400. doi: 10.1074/jbc.M109.041863.