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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16219-0.05 | 0.05 ml | $460 |
PathPlus™ Monoclonal Mouse anti‑Human CD207 / Langerin Antibody (clone 12D6, IHC) LS‑B16219
PathPlus™ Monoclonal Mouse anti‑Human CD207 / Langerin Antibody (clone 12D6, IHC) LS‑B16219
Note: This antibody replaces LS-C312086
Antibody:
CD207 / Langerin Mouse anti-Human Monoclonal (12D6) Antibody
Application:
IHC, IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
CD207 / Langerin Mouse anti-Human Monoclonal (12D6) Antibody
Application:
IHC, IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
CD207 (also called langerin) is a calcium-dependent lectin with binding specific for mannose. It is the major cell-surface receptor for Candida species, Saccharomyces species, and Malassezia furfur on Langerhans cells (dendritic cells of the epidermis and mucosa). It has been proposed that mannose binding leads to antigen internalization into cytoplasmic Birbeck granules in Langerhans cells, comprising a nonclassical antigen-processing pathway. CD207 is expressed in Langerhans cells. It is also expressed in gliomas (astrocytoma, malignant ependymoma) but not normal brain. Staining is used to identify Langerhans cells.
References: Immunity. 2000;12(1):71-81. PMID: 10661407; Immunol Res. 2003;28(2):93-107. doi: 10.1385/IR:28:2:93; Mol Immunol. 2010;47(6):1216-1225. doi: 10.1016/j.molimm.2009.12.016; Cell Mol Immunol. 2017;14(4):360-370. doi: 10.1038/cmi.2015.87; J Biol Chem. 2010;285(9):6390-6400. doi: 10.1074/jbc.M109.041863.
Target
Human CD207 / Langerin
Synonyms
CD207 | CD207 antigen, langerin | CD207 antigen | CD207 molecule, langerin | CLEC4K | Langerin
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG2b,k
Monoclonal
Clone
12D6
Conjugations
Unconjugated
Purification
Tissue culture supernatant
Modifications
Unmodified.
Also available Unmodified or Ready-to-Use.
Applications
- IHC
- IHC - Paraffin (1:25 - 1:100)
- IHC - Frozen (1:25 - 1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: Paraffin and frozen. Control tissue: Skin, Histocytosis. Localization: Cytoplasmic.
Presentation
Filter sterilized and diluted in buffer, pH 7.5, BSA, Sodium Azide
Storage
Store at 2-8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CD207 / Langerin
Validation
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CD207 / Langerin Antibody (clone 12D6) for IHC LS-B16219 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC - Paraffin, IHC - Frozen
Species:
Human
Applications:
IHC - Paraffin, IHC - Frozen
Species:
Mouse, Human, Rat
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/30/2024
Date Requested: 12/30/2024
