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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16456-50 | 50 µl (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human TUBB / Beta Tubulin Antibody (aa174‑428, IHC, WB) LS‑B16456
PathPlus™ Polyclonal Rabbit anti‑Human TUBB / Beta Tubulin Antibody (aa174‑428, IHC, WB) LS‑B16456
Note: This antibody replaces LS-C185869
Antibody:
TUBB / Beta Tubulin Rabbit anti-Human Polyclonal (aa174-428) Antibody
Application:
IHC-P, ICC, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
TUBB / Beta Tubulin Rabbit anti-Human Polyclonal (aa174-428) Antibody
Application:
IHC-P, ICC, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
TUBB (beta tubulin class I) is protein that forms a dimer with alpha tubulin to act as a major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain (TUBB) and one at a non-exchangeable site on the alpha chain. Inherited TUBB mutations lead to development brain defects including cortical dysplasia, while somatic mutations are correlated with drug resistance in cancer. In immunohistochemistry, TUBB has variable degrees of cytoplasmic positivity in all tissues.
References: Hum Genet. 1994 Jan;93(1):42-6, PMID: 8270253; Biochem Biophys Res Commun. 2016 Aug 5;476(4):273-279, PMID: 27233604; J Biomol Struct Dyn. 2015;33(12):2530-40, PMID: 26081685; Mol Cancer Ther. 2011 Aug;10(8):1419-29, PMID: 21653684
Target
Human TUBB / Beta Tubulin
Synonyms
TUBB | Beta Tubulin | Beta 5-tubulin | Beta-4 tubulin | Beta1-tubulin | M40 | Tubulin beta-5 chain | Beta Ib tubulin | Class I beta-tubulin | OK/SW-cl.56 | TUBB5 | Tubulin beta chain | Tubulin beta polypeptide | Tubulin beta-1 chain | Tubulin, beta class I | Tubulin, beta polypeptide
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Recombinant protein encompassing a sequence within the center region of human beta Tubulin. The exact sequence is proprietary.
Epitope
aa174-428
Specificity
Human TUBB / Beta Tubulin
Applications
- IHC - Paraffin (10 µg/ml)
- ICC (1:100 - 1:1000)
- Western blot (1:500 - 1:3000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
0.1 M Tris, pH 7, 0.1 M Glycine, 10% Glycerol, 0.01% Thimerosal
Storage
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TUBB / Beta Tubulin
Validation
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ TUBB / Beta Tubulin Antibody (aa174-428) for IHC, ICC, WB/Western LS-B16456 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
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Species:
Human, Mouse, Rat, Bovine, Rabbit, Chicken, Frog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat, Bovine, Rabbit, Chicken, Frog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Monkey, Mouse, Rat
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/29/2024
Date Requested: 12/29/2024
