Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
| Catalog Number | Size | Price |
|---|---|---|
| LS-A1449-50 | 50 µg (1 mg/ml) | $440 |
1 of 5
2 of 5
3 of 5
4 of 5
5 of 5
PathPlus™ Polyclonal Rabbit anti‑Human TSH Receptor / TSHR Antibody (C‑Terminus, IHC) LS‑A1449
PathPlus™ Polyclonal Rabbit anti‑Human TSH Receptor / TSHR Antibody (C‑Terminus, IHC) LS‑A1449
Antibody:
TSH Receptor / TSHR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
TSH Receptor / TSHR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
TSHR (thyroid stimulating hormone receptor) is a thyrotropin and glycoprotein hormone receptor centrally involved in controlling thyroid cell metabolism. TSHR interacts with both TSH and autoantibodies against TSHR (thyroid-stimulating immunoglobulins, TSI). Mutations in the receptor cause hyperthyroidism including gestational hyperthyroidism (hypersensitivity to chorionic gonadotropin) and Grave's disease (autoimmune hyperthyroidism), for which TSHR is a therapeutic target.
References: Expert Opin Ther Targets. 2017 Apr;21(4):427-432, PMID: 28127991
Target
Human TSH Receptor / TSHR
Synonyms
TSHR | CHNG1 | HTSHR-I | LGR3 | Thyrotrophin receptor | TSH-R | TSH receptor | Thyrotropin receptor
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Dog, Guinea pig, Horse, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from C-Terminus of human TSH Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bat, Dog, Elephant, Horse, Pig, Guinea pig (94%); Mouse, Rat, Sheep, Cat, Bovine, Hamster, Panda, Rabbit, Opossum (89%).
Epitope
C-Terminus
Specificity
Human TSH Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except LHCGR (42%).
Applications
- IHC
- IHC - Paraffin (4 - 13 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TSH Receptor / TSHR
Validation
Thyroid Papillary Carcinoma
Thyroid Papillary Carcinoma
Thyroid, Follicular Carcinoma
Thyroid, Follicular Carcinoma
Thyroid Papillary Carcinoma
Thyroid Papillary Carcinoma
Anti-TSH Receptor antibody IHC of human thyroid, follicular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TSH Receptor antibody IHC of human thyroid, follicular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TSH Receptor / TSHR antibody IHC of human Thyroid, Follicular Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TSH Receptor / TSHR antibody IHC of human Thyroid, Follicular Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ TSH Receptor / TSHR Antibody (C-Terminus) for IHC LS-A1449 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/23/2024
Date Requested: 11/23/2024
