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Thyrotropin Receptor, a Glycoprotein Hormone Receptor, plays a central role in controlling thyroid cell metabolism. The TSH receptor can interact with both TSH and autoantibodies against the TSH receptor (thyroid-stimulating immunoglobulins, TSI). Mutations in the receptor are the cause for hyperthyroidism such as gestational hyperthyroidism (hypersensitivity to chorionic gonadotropin) and Grave's disease (autoimmune hyperthyroidism). Multiple isoforms of the thyrotropin receptor are produced by altervative splicing.
Gene Name: | thyroid stimulating hormone receptor |
Family/Subfamily: | GPCR , Glycoprotein hormone |
Synonyms: | TSHR, CHNG1, HTSHR-I, LGR3, Thyrotrophin receptor, TSH-R, TSH receptor, Thyrotropin receptor |
Target Sequences: | NM_000369 NP_000360.2 P16473 |
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