SORT1 (Sortilin) is a protein that functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. It is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR), and is also required for protein transport from the Golgi apparatus to the endosomes. In the nervous system, SORT1 promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). It also acts as a receptor for neurotensin. It may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. It is likely required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804