SLC2A1 (also known as GLUT1) is a facilitative glucose transporter protein involved in constitutive or basal glucose uptake. It is capable of transporting a wide range of aldoses, including both pentoses and hexoses, across the plasma membrane. SLC2A1 mutations lead to GLUT1 deficiency syndrome 1 and 2, dystonia, idiopathic generalized epilepsy and stomatin-deficient cryohydrocytosis. GLUT1 is also relevant to Alzheimer’s disease and neurodegenerative disorders, as lower levels of GLUT1 have been found to contribute to vascular degeneration, diminished neuronal activity, reductions in blood flow and blood-brain barrier degeneration. In immunohistochemistry, SLC2A1 has highest cytoplasmic positivity in trophoblasts, erythrocytes, and endothelial cells in the blood-brain barrier, and also has lower levels of staining in most other tissues. References: Annual Review of Nutrition. 16: 235–56, PMID: 8839927; Nucleic Acids Research. 45 (D1): D158–D169. January 2017, PMID: 27899622; Pflügers Archiv. 2004. 447 (5): 480–9, PMID: 12750891; Nat Neurosci. 2015 Apr;18(4):521-530, PMID: 25730668;