NGFR (Nerve Growth Factor Receptor, CD271, TNFRSF16) is a member of the TNFR superfamily, and is a low-affinity receptor subunit for nerve growth factor and multiple neurotrophins that stimulate neuron growth and differentiation. NGFR is expressed in peripheral nerves, reticular fibers of germinal centers and the liver, myoepithelial cells, some mesenchymal stromal cells, and glandular epithelium of the prostate and seminal vesicle. It is also a determinant of stem-like properties and tumorigenicity in malignant melanomas. It is expressed in neural crest stem cells and is regarded as a neural crest stem cell marker. It is expressed on the cell membrane. References: Nature Scientific Reports 2018 8, article 9321; PLoS One https://doi.org/10.1371/journal.pone.0092596; Front med 2017 https://doi.org/10.3389/fmed.2017.00022