Glucagon-like peptide 1 receptor (GLP1R) is a receptor for glucagon and glucagon-like peptide-1 (GLP1). It is involved in insulin synthesis and release, blood glucose homeostasis, appetite control, memory and learning, as well as control of breathing and heart rate. Stimulation of GLP1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). In immunohistochemistry, GLP1R has highest membranous positivity on pancreatic beta cells, it is expressed on neurons in the brain and nervous system, and it is also found in the stomach, salivary gland, heart muscle, gallbladder, salivary gland, duodenum and at low levels in a few other tissues. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804