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GLP1R / GLP-1 Receptor
glucagon-like peptide 1 receptor
GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003).
| Gene Name: | glucagon-like peptide 1 receptor |
| Family/Subfamily: | GPCR , Glucagon |
| Synonyms: | GLP1R, GLP-1-R, GLP-1 receptor, GLP-1R, GLP-I receptor, Glp1 receptor |
| Target Sequences: | NM_002062 NP_002053.3 P43220 |
Publications (12)
1
Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Diabetes. 2011 60:2397-406. (IHC-Fr; Mouse)
[Full Text Article]
[PubMed:21810596]
[PMC:PMC3161330]
Related Antibodies: LS-A1206, LS-A1205.
2
Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ. The Journal of clinical investigation. 2012 122:388-402. (IHC; Mouse)
[Full Text Article]
[PubMed:22182839]
[PMC:PMC3248276]
Related Antibodies: LS-A1205.
3
GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic Male ApoE–/– Mice. Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, Brown TJ, Streutker C, Holland D, Cao X, Baggio LL, Drucker DJ. Endocrinology. 2013 154:127-39. (WB; Mouse, Hamster)
[Full Text Article]
[PubMed:23183176]
Related Antibodies: LS-A1205.
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Neuroscience
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$460
Neuroscience
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Fast Shipping
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Mouse, Dog, Hamster, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (aa250-350) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
GLP1R / GLP-1 Receptor Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$513; 100 µg/$832
GLP1R / GLP-1 Receptor Goat anti-Mouse Polyclonal (aa129-140) Antibody
Mouse
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
GLP1R / GLP-1 Receptor Goat anti-Human Polyclonal (aa211-222) Antibody
Rabbit, Mouse, Guinea pig, Rat, Pig, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
E. coli
His
18.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Yeast
His
16.3 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
E. coli
10His, N-terminus
53.6 kDa
100 µg/$1,293; 20 µg/$854
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
E. coli
6His, N-terminus
21.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (aa24-145) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (80-160 aa, Internal) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
GLP1R / GLP-1 Receptor Rabbit anti-Mouse Polyclonal (aa101-150) Antibody
Mouse
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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