Mouse MDM2

Rabbit

Mouse (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Purified IgG

Unmodified

Synthetic peptide corresponding to aa 177-195 of mouse Mdm2.

aa177-195

Detects murine Mdm2, a nuclear phosphoprotein that controls intracellular levels of the tumor suppressor protein p53 by ubiquitination and subsequent proteasomal degradation. Mdm2 also interacts with the retinoblastoma (RB) protein and E2F-1, to promote G1-S phase transition in the cell cycle. Mdm2 activity is controlled by self-ubiquitination; however activation of the PI3K/PKB pathway leads to phosphorylation of Mdm2 at Ser185, which stabilizes the protein.

• Western blot (1:500 - 1:2000)
• ELISA (1:3000 - 1:12000)

Western Blot: LS-C42649 detects a band of approximately 90kD in mouse MEF cell lysates.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q00987 NCBI: NM_002392 NP_002383.2