Target
Human FKBP38 / FKBP8
Synonyms
FKBP8 | 38 kDa FKBP | 38 kDa FK506-binding protein | FKBP-8 | FK506-binding protein 8 | FKBP38 | HFKBP38 | FKBP-38 | Rotamase | FK506 binding protein 8, 38kDa | FK506-binding protein 8 (38kD) | FKBPr38 | PPIase FKBP8
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Horseradish Peroxidase.
Also available
Unconjugated or conjugated with
Biotin,
FITC.
Immunogen
Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP8 protein (58-190AA)
Specificity
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.