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Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Gene Name: | FK506 binding protein 8, 38kDa |
Synonyms: | FKBP8, 38 kDa FKBP, 38 kDa FK506-binding protein, FKBP-8, FK506-binding protein 8, FKBP38, HFKBP38, FKBP-38, Rotamase, FK506 binding protein 8, 38kDa, FK506-binding protein 8 (38kD), FKBPr38, PPIase FKBP8 |
Target Sequences: | NM_012181 NP_036313.3 Q14318 |
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