Human CTLA4 / CD152

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

ANC152.2/8H5

R. Phycoerythrin. Also available Unconjugated or conjugated with Biotin, FITC.

Gel filtration

Unmodified

Stimulated human PBL’s and human CD152 Ig fusion protein.

CTLA-4 expressed on activated T cells.

• Flow Cytometry
• ELISA
• Functional Assay
• Applications tested for the base form of this product only

Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

50 mM Sodium Phosphate, pH 7.5, 150 mM NaCl, 500 mM KCl, 0.04% Sodium Azide, 15% Glycerol, 0.2% BSA

Store at 4°C. Do not freeze.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P16410 NCBI: NM_005214 NP_005205.2