Target
Human CTLA4 / CD152
Synonyms
CTLA4 | CD152 | CELIAC3 | CD152 antigen | CTLA-4 | Celiac disease 3 | IDDM12 | GRD4 | GSE | CD152 isoform
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1,k
Monoclonal
Conjugations
Unconjugated.
Also available conjugated with
Biotin,
RPE,
FITC.
Purification
Protein A purified
Modifications
Unmodified.
Also available
Fab'2,
Fab,
Azide-free.
Immunogen
Stimulated human PBL’s and human CD152 Ig fusion protein.
Specificity
CTLA-4 expressed on activated T cells.
Applications
- Flow Cytometry
- ELISA
- Functional Assay
Usage
Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model.
Presentation
50 mM Sodium Phosphate, pH 7.5, 150 mM NaCl, 100 mM KCl, 0.5 mg/ml Gentamicin
Storage
Store at 4°C. Do not freeze.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee