Human CAPN1 / Calpain 1

Rabbit

Human, Mouse, Rat (tested or 100% immunogen sequence identity)

Horse (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the middle region of human CAPNL1 (EWNNVDPYERDQLRV, aa313-327 of UniProt P07384). Percent identity by BLAST analysis: Human (100%); Ferret, Horse (93%); Mouse, Rat, Cat, Bat, Pig, Dog (87%); Bovine, Hamster, Elephant, Rabbit (80%).

aa313-327

Human CAPN1 / Calpain 1

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• IHC - Frozen (0.5 - 1 µg/ml)
• ICC (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Calpain-1 catalytic subunit is a protein that in humans is encoded by the CAPN1 gene. Calpain is an intracellular protease that requires calcium for its catalytic activity. Two isozymes, CAPN1 (mu-calpain) and CAPN2 (m-calpain), with different calcium requirements, have been identified. Both are heterodimers composed of L (large, catalytic, 82 kD) and S (small, regulatory, 30 kD) subunits. The isozymes share an identical S subunit, with the differences arising from the L subunits. By quantitative RT-PCR, Ueyama et al. (1998) found that expression of Calpain1/2 mRNA was significantly increased in muscle biopsy samples derived from 5 men with progressive muscular dystrophy (e.g., DMD. 310200) and 2 men and 3 women with amyotrophic lateral sclerosis (ALS. 105400) compared with controls. Using cDNA clones as probes, Ohno et al. (1989, 1990) assign CAPNL1 to chromosome 11.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P07384 NCBI: BC008751 AAH08751.1