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Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals By similarity. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.
Gene Name: | zinc finger and BTB domain containing 7A |
Synonyms: | ZBTB7A, Factor binding IST protein 1, FBI1, HIV-1 1st-binding protein 1, FBI-1, LRF, Lymphoma related factor, TIP21, TTF-I-interacting peptide 21, Zinc finger protein 857A, ZBTB7, ZNF857A, Pokemon |
Target Sequences: | NM_015898 NP_056982.1 O95365 |
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