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YAP / YAP1
Yes-associated protein 1
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
| Gene Name: | Yes-associated protein 1 |
| Synonyms: | YAP1, 65 kDa Yes-associated protein, YAP, Yes-associated protein beta, Yes-associated protein delta, Yorkie homolog, YAP2, Yes-associated protein 1, Yes-associated protein 2, YKI, YAP65 |
| Target Sequences: | NM_006106 NP_006097.2 P46937 |
Publications (2)
1
A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma. Jung Hyun Jo, Dawoon E Jung, Hee Seung Lee, Soo Been Park, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Sangsook Cho, Si Young Song. International journal of cancer. Journal international du cancer. 2022 November;151:1565-1577. [Full Text Article]
[PubMed:35657348]
[PMC:PMC9545559]
2
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis. Feiyang Ma , Pei-Suen Tsou , Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A Hile, Paul W Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L Modlin, John Varga, Lam C Tsoi, Robert Lafyatis, J Michelle Kahlenberg, Allison C Billi, Dinesh Khanna, Johann E Gudjonsson. Nature communications. 2024 January;15:210. [Full Text Article]
[PubMed:38172207]
[PMC:PMC10764940]
Related Antibodies: LS-C331201.
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YAP / YAP1 Mouse anti-Human Monoclonal (2F12) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
YAP / YAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC-P, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
YAP / YAP1 Rabbit anti-Human Polyclonal (aa351-400) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
YAP / YAP1 Rabbit anti-Human Polyclonal (aa351-400) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Rabbit, Mouse, Dog, Sheep, Bovine, Bat, Pig, Horse, Rat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
YAP / YAP1 Mouse anti-Human Monoclonal (1A12) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
YAP / YAP1 Mouse anti-Human Monoclonal (2H1) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
YAP / YAP1 Mouse anti-Human Monoclonal (1A12) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
YAP / YAP1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Sheep, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
YAP / YAP1 Rabbit anti-Human Polyclonal (aa350-400) Antibody
Human
IHC, IHC-P, IP
Unconjugated
50 µl/$460
YAP / YAP1 Rabbit anti-Human Polyclonal (aa350-400) Antibody
Human
IF, IHC, IHC-P
Unconjugated
50 µl/$460
YAP / YAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
YAP / YAP1 Rabbit anti-Human Polyclonal (Ser94) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 ml/$475
YAP / YAP1 Rabbit anti-Human Polyclonal (aa93-142) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
YAP / YAP1 Rabbit anti-Human Polyclonal Antibody
Zebrafish, Mouse, Human
Flo, IF, IHC, IP, WB
Unconjugated
20 µl/$299; 100 µl/$409
YAP / YAP1 Rabbit anti-Human Polyclonal (pSer127) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
YAP / YAP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
YAP / YAP1 Mouse anti-Human Monoclonal (1A12) Antibody
Human
Flo, IHC, WB
Unconjugated
100 µg/$503
YAP / YAP1 Rabbit anti-Human Polyclonal (250-330 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
YAP / YAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
YAP / YAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ChrIP, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$688
YAP / YAP1 Rabbit anti-Human Polyclonal (Gln295) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
YAP / YAP1 Rabbit anti-Human Polyclonal (AP) Antibody
Mouse, Rat, Human
IF, IHC, WB
AP Conjugated
20 µl/$275; 100 µl/$389
YAP / YAP1 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
YAP / YAP1 Rabbit anti-Human Polyclonal (pSer127) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
YAP / YAP1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
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