Human YAP / YAP1

Rabbit

Human, Mouse, Rat (tested or 100% immunogen sequence identity)

Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser94 of human YAP1.

Ser94

YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction.

• Western blot (1:1000 - 1:10000)
• ELISA (1:5000 - 1:20000)

YAP1 (Ser94) Antibody recognizes endogenous and transfected levels of YAP1 when phosphorylated at Ser94 (Ser79 in mouse and rat).

PBS, pH 7.4, 1% BSA, 0.1% sodium azide, 50% glycerol.

Store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P46937 NCBI: NM_006106 NP_006097.2