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XRCC6 / Ku70
X-ray repair complementing defective repair in Chinese hamster cells 6
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.
| Gene Name: | X-ray repair complementing defective repair in Chinese hamster cells 6 |
| Synonyms: | XRCC6, 5-dRP lyase Ku70, 70 kDa subunit of Ku antigen, CTCBF, DNA repair protein XRCC6, D22S671, D22S731, G22P1, Ku autoantigen, 70kDa, Ku autoantigen p70 subunit, Thyroid-lupus autoantigen p70, TLAA, CTC75, KU70, ML8, Thyroid-lupus autoantigen |
| Target Sequences: | NM_001469 NP_001460.1 P12956 |
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