WNT5A

wingless-type MMTV integration site family, member 5A

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

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Products

Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (11)

Target

WNT5A (13)

Publications

No (13)

Tag

10His, N-terminus + Myc, C-terminus (1)

10His-SUMO, N-terminus + Myc, C-terminus (1)

6His, N-terminus (3)

6His-SUMO, N-terminus (1)

GST (2)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (10)

Mouse (2)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (6)

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Human WNT5A Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G136612

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

37.8 kDa

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Mouse WNT5A Protein (Recombinant GST) (aa62-380) - LS-G16280

Source:

E. coli

Tag:

GST

Molecular Weight:

62.2 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Human WNT5A Protein (Recombinant GST) (Full Length) - LS-G30902

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.7 kDa

Price:

2 µg/$439

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Human WNT5A Protein (Recombinant 6His-SUMO, N-terminus) (aa62-380) - LS-G64216

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,307; 100 µg/$410; 20 µg/$317

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Human WNT5A Protein (Recombinant GST, N-terminus) (aa201-300) - LS-G60525

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human WNT5A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67345

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.2 kDa

Price:

20 µg/$1,107

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WNT5A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100040

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.2 kDa

Price:

100 µg/$494

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Human WNT5A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79602

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.2 kDa

Price:

20 µg/$150

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Human WNT5A Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G137145

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

39.8 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human WNT5A Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa62-380) - LS-G64212

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human WNT5A Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa62-380) - LS-G64217

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human WNT5A Protein (Recombinant 6His, N-terminus) (Ile62-Lys380) - LS-G132594

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

39.5

Price:

10 µg/$292; 200 µg/$1,018; 1 mg/$2,168; 5 mg/$3,571; 2 mg/$2,359

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Mouse WNT5A Protein (Recombinant GST, N-terminus) - LS-G132869

Source:

E. coli

Tag:

GST, N-terminus

Molecular Weight:

62kDa

Price:

10 µg/$362; 50 µg/$902; 200 µg/$1,553; 100 µg/$1,325; 1 mg/$2,881; 500 µg/$2,369; 5 mg/$6,301; 2 mg/$3,361

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