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WNT5A

wingless-type MMTV integration site family, member 5A

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Gene Name:	wingless-type MMTV integration site family, member 5A
Family/Subfamily:	WNT , not assigned-WNT
Synonyms:	WNT5A, HWNT5A, Protein Wnt-5a, WNT-5A protein
Target Sequences:	NM_003392 NP_003383.2 P41221

Publications (9)

Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis. Geng M, Cao YC, Chen YJ, Jiang H, Bi LQ, Liu XH. World journal of gastroenterology : WJG. 2012 18:1328-38. (WB, IHC-P; Human) [Full Text Article] [PubMed:22493546] [PMC:PMC3319959]

Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-ß and WNT7B in Human Lung Fibroblasts. Newman DR, Sills WS, Hanrahan K, Ziegler A, Tidd KM, Cook E, Sannes PL. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2016 64:99-111. (IHC; Human) [Full Text Article] [PubMed:26538547] [PMC:PMC4812680] Related Antibodies: LS-B4565.

Wingless ligand 5a is a critical regulator of placental growth and survival. Meinhardt G, Saleh L, Otti GR, Haider S, Velicky P, Fiala C, Pollheimer J, Knöfler M. Scientific reports. 2016 6:28127. (ELISA; Human) [Full Text Article] [PubMed:27311852] [PMC:PMC4911582] Related Antibodies: LS-C133974.

Optimization, validation, and identification of two reliable antibodies for immunodetection of WNT5A. Prgomet Z, Andersson T, Lindberg P. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2017 92:46-58. (IHC; Human) [Full Text Article] [PubMed:28157427] Related Antibodies: LS-B3859.

SCAPs Regulate Differentiation of DFSCs During Tooth Root Development in Swine. Wu X, Hu L, Li Y, Li Y, Wang F, Ma P, Wang J, Zhang C, Jiang C, Wang S. International journal of medical sciences. 2018 January;15:291-299. (Human) [Full Text Article] [PubMed:29511365] [PMC:PMC5835700] Related Antibodies: LS-B4565.

Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis. Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G. Journal of dental research. 2017 May;96:571-577. [Full Text Article] [PubMed:28095260] [PMC:PMC5453495] Related Antibodies: LS-B3859.

Role of Wnt5a in suppressing invasiveness of hepatocellular carcinoma via epithelial-mesenchymal transition. Kazuki Wakizaka, Toshiya Kamiyama, Kenji Wakayama, Tatsuya Orimo, Shingo Shimada, Akihisa Nagatsu, Hirofumi Kamachi, Hideki Yokoo, Moto Fukai, Nozomi Kobayashi, Tomoko Mitsuhashi, Akinobu Taketomi. Oncology letters. 2020 November;20:268. [Full Text Article] [PubMed:32989402] [PMC:PMC7517569] Related Antibodies: LS-C47384.

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. D H Wilson, E J Jarman, R P Mellin, M L Wilson, S H Waddell, P Tsokkou, N T Younger, A Raven, S R Bhalla, A T R Noll, S W Olde Damink, F G Schaap, P Chen, D O Bates, J M Banales, C H Dean, D J Henderson, O J Sansom, T J Kendall, L Boulter. Nature communications. 2020 Jan;11:445. [Full Text Article] [PubMed:31974352] [PMC:PMC6978415] Related Antibodies: LS-B4565.

Wnt Signaling Drives Prostate Cancer Bone Metastatic Tropism and Invasion. Yugang Wang, Udit Singhal, Yuanyuan Qiao, Tadas Kasputis, Jae-Seung Chung, Huiru Zhao, Farah Chammaa, Jacob A Belardo, Therese M Roth, Hao Zhang, Alexander B Zaslavsky, Ganesh S Palapattu, Kenneth J Pienta, Arul M Chinnaiyan, Russell S Taichman, Frank C Cackowski, Todd M Morgan. Translational oncology. 2020 Apr;13:100747. [Full Text Article] [PubMed:32217460] [PMC:PMC7109463]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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