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WAS / WASP

Wiskott-Aldrich syndrome

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Gene Name: Wiskott-Aldrich syndrome
Synonyms: WAS, Eczema-thrombocytopenia, IMD2, SCNX, WASP, THC, THC1, Wiskott-Aldrich syndrome, Thrombocytopenia 1 (X-linked)
Target Sequences: NM_000377 NP_000368.1 P42768

Publications (1)

1
Inadequate Activation of ?dT- and B-cells in Patient with Wiskott-Aldrich Syndrome (WAS) Portrayed by TRG and IGH Repertoire Analyses. Dahlia Palevski, Amos Simon, Atar Lev, Raz Somech, Yu Nee Lee. Journal of clinical immunology. 2022 August; [Full Text Article] [PubMed:36044170] [PMC:PMC9840590] Related Antibodies: LS-C273428.

☰ Filters
Antibodies (56)
Proteins (6)
ELISA Kits (3)
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WAS / WASP (65)
Human (50)
Mouse (22)
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WB (52)
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rabbit (53)
mouse (2)
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Product Group
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monoclonal mc (3)
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aa1-298 (8)
aa39-251 (8)
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aa205-234 (7)
pTyr290 (3)
230-310 aa (2)
Glu284 (1)
aa129-156 (1)
aa221-233 (1)
aa256-305 (1)
aa400-C-term (1)
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WAS / WASP Antibody - WAS Antibody IHC of formalin-fixed and paraffin-embedded tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa116-144) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
WAS / WASP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
WAS / WASP Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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WAS / WASP Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
WAS / WASP Antibody - Immunohistochemical analysis of WASP (pY290) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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WAS / WASP Rabbit anti-Human Polyclonal (pTyr290) Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
WAS / WASP Protein - Recombinant Wiskott Aldrich Syndrome Protein By SDS-PAGE
Select
E. coli
His-T7
26.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
WAS / WASP Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using WASP (Ab-290) antibody.
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WAS / WASP Rabbit anti-Human Polyclonal (p290) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
WAS / WASP Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using WASP (Phospho-Tyr290) antibody.
Select
WAS / WASP Rabbit anti-Human Polyclonal (pTyr290) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
Select
WAS / WASP Rabbit anti-Human Monoclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$688
WAS / WASP Antibody - WASP antibody IHC-paraffin. IHC(P): Human Lung Cancer Tissue.
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa129-156) Antibody
Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
WAS / WASP Antibody
Select
WAS / WASP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$575
WAS / WASP Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
WAS / WASP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa116-144) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa116-144) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa116-144) (FITC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa116-144) (PE) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa116-144) (APC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa116-144) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
WAS / WASP Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
WAS / WASP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
WAS / WASP Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
WAS / WASP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$485
WAS / WASP Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using WASP (Phospho-Tyr290) Antibody. The picture on the right is blocked with the phospho peptide.
Select
WAS / WASP Rabbit anti-Human Polyclonal (pTyr290) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
WAS / WASP Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using WASP Antibody. The picture on the right is blocked with the synthesized peptide.
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa256-305) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
WAS / WASP Rabbit anti-Human Polyclonal (230-310 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
WAS / WASP Antibody - Western blot of WASP antibody
Select
WAS / WASP Rabbit anti-Human Polyclonal (230-310 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
WAS / WASP Antibody - Western blot of WAS / WASP antibody.
Select
WAS / WASP Rabbit anti-Human Polyclonal (aa39-251) Antibody
Pig, Human
ICC, IP, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
Select
WAS / WASP Mouse anti-Human Monoclonal (7B10E4) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
Viewing 1-25 of 65 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).