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VPS35 belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.
Gene Name: | Vacuolar protein sorting-associated protein 35 |
Synonyms: | VPS35, MEM3, Maternal-embryonic 3, Vesicle protein sorting 35, PARK17, HVPS35 |
Target Sequences: | NM_018206 NP_060676.2 Q96QK1 |
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