VHL / Von Hippel Lindau

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

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Products

Antibodies (47)

Proteins (10)

ELISA Kits (7)

Type

Custom (4)

Over-Expression Lysate (4)

Primary (47)

Recombinant (6)

Sandwich (3)

Target

VHL / Von Hippel Lindau (64)

Reactivity

Human (42)

Mouse (21)

Rat (27)

Bat (4)

Chimpanzee (3)

Dog (2)

Gibbon (3)

Guinea pig (3)

Monkey (4)

Orangutan (3)

Pig (3)

Rabbit (1)

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Application

IHC (19)

IHC-P (5)

WB (34)

Flo (3)

ELISA (18)

ICC (1)

IF (5)

Peptide-ELISA (4)

Host

rabbit (38)

mouse (7)

goat (2)

Product Group

IHCPlus (1)

Isotype

IgG (17)

IgG1,k (1)

IgG2b (2)

IgG2b,k (3)

Clonality

monoclonal mc (7)

polyclonal pc (40)

Clone

1G12 (1)

ABT-PVHL (1)

AT82B10 (1)

OTI1E1 (2)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

APC (1)

APC Conjugated (1)

Biotin Conjugated (4)

Carrier-free (1)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (35)

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Epitope

aa6-175 (8)

aa27-76 (4)

aa43-71 (3)

10-90 aa (2)

Ab-68 (1)

Internal Region (1)

N-Terminus (1)

aa1-213 (1)

aa167-179 (1)

aa181-210 (1)

pSer68 (1)

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Publications

No (64)

Sample Type

Cell Culture Supernatants (1)

Plasma (2)

Serum (2)

Tissue Homogenates (2)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Rat (1)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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IHC-plus™ VHL / Von Hippel Lindau Antibody (aa167-179) LS-B10235

(4.0) Rating

Antibody:

VHL / Von Hippel Lindau Goat anti-Human Polyclonal (aa167-179) Antibody

Reactivity:

Rabbit, Mouse, Dog, Rat, Bat, Human, Monkey

Applications:

ELISA, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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VHL / Von Hippel Lindau Antibody (aa43-71) LS-C160525

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (aa43-71) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

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VHL / Von Hippel Lindau Antibody (clone OTI1E1) LS-C174737

Antibody:

VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (OTI1E1) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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VHL / Von Hippel Lindau Antibody (clone OTI1E1, Carrier-free) LS-C788118

Antibody:

VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (Carrier-free) (OTI1E1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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Human VHL / Von Hippel Lindau (Sandwich ELISA) ELISA Kit - LS-F12950

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Human VHL / Von Hippel Lindau Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79583

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.5 kDa

Price:

20 µg/$150

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Human VHL / Von Hippel Lindau Protein (Recombinant His) - LS-G3595

Source:

E. coli

Tag:

His

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human VHL / Von Hippel Lindau Protein (Recombinant GST, N-terminus) (Full Length) - LS-G30875

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

46.1 kDa

Price:

2 µg/$439

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VHL / Von Hippel Lindau Antibody (aa181-210) LS-C99277

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (aa181-210) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human VHL / Von Hippel Lindau Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G137134

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.2 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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VHL / Von Hippel Lindau Antibody (aa43-71, Biotin) LS-C530201

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (aa43-71) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$697

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Human VHL / Von Hippel Lindau (Sandwich ELISA) ELISA Kit - LS-F33492

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$579

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VHL / Von Hippel Lindau Antibody (Internal Region, Biotin) LS-C742398

Antibody:

VHL / Von Hippel Lindau Goat anti-Human Polyclonal (Internal Region) (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, Peptide-ELISA, WB

Format:

Biotin Conjugated

Price:

100 µg/$503

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VHL / Von Hippel Lindau Antibody (clone 1G12) LS-C198428

Antibody:

VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (1G12) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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Rat VHL / Von Hippel Lindau Protein (Recombinant His, N-terminus) (aa6-175) - LS-G26027

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

23.3 kDa

Price:

10 µg/$284; 50 µg/$462; 200 µg/$922; 1 mg/$2,042; 5 mg/$3,221; 2 mg/$2,231

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VHL / Von Hippel Lindau Antibody LS-C661549

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$341

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VHL / Von Hippel Lindau Antibody LS-C832776

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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VHL / Von Hippel Lindau Antibody (clone AT82B10) LS-C755589

Antibody:

VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (AT82B10) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

50 µl/$303; 100 µl/$365

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VHL / Von Hippel Lindau Antibody (clone ABT-PVHL) LS-C744561

Antibody:

VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (ABT-PVHL) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

50 µl/$268; 100 µl/$316

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VHL / Von Hippel Lindau Antibody LS-C808647

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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VHL / Von Hippel Lindau Antibody (10-90 aa) LS-C386647

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (10-90 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

VHL / Von Hippel Lindau Antibody (10-90 aa) LS-C381704

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (10-90 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

VHL / Von Hippel Lindau Antibody LS-C743308

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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VHL / Von Hippel Lindau Antibody (Ab-68) LS-C825643

Antibody:

VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (Ab-68) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

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VHL / Von Hippel Lindau Antibody LS-C11035

Antibody:

VHL / Von Hippel Lindau Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$586

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