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| Catalog Number | Size | Price |
|---|---|---|
| LS-G137134-20 | 20 µg | $364 |
| LS-G137134-100 | 100 µg | $500 |
| LS-G137134-1 | 1 mg | $1,679 |
Human VHL / Von Hippel Lindau Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G137134
Human VHL / Von Hippel Lindau Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G137134
Description:
VHL / Von Hippel Lindau Protein LS-G137134 is a Recombinant Human VHL / Von Hippel Lindau produced in E. coli 1-213aa with 6His, N-terminus tag(s). For Research Use Only
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(800) 227-6666
(800) 227-6666For Research Use Only
Specifications
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Popular VHL / Von Hippel Lindau Proteins
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Overview
Description:
VHL / Von Hippel Lindau Protein LS-G137134 is a Recombinant Human VHL / Von Hippel Lindau produced in E. coli 1-213aa with 6His, N-terminus tag(s). For Research Use Only
Specifications
Type
Recombinant Protein
Target
VHL / Von Hippel Lindau
Synonyms
VHL | Elongin binding protein | HRCA1 | RCA1 | VHL1 | Von Hippel-Lindau syndrome | Protein G7 | PVHL
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Tag
6His, N-terminus
Region
1-213aa
Predicted Molecular Weight
28.2 kDa
AA Sequence
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Expression System
E. coli
Source Species
E. coli
Purification
Greater than 85% by SDS-PAGE
Usage Summary
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Bio-Activity
Not Tested
Endotoxin
Not Tested
Presentation
Lyophilized from 10mM Tris-HCl, 1mM EDTA, 6% Trehalose, pH 8.0.
Reconstitution
Briefly centrifuge vial prior to opening. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. Add 5-50% of glycerol (final concentration).
Storage
Short term: store at 4°C for up to 1 week. Long term: store at -20°C regardless of reconstitution; aliquot to avoid freeze-thaw cycles after reconstitution.
Restrictions
For research use only. Intended for use by laboratory professionals.
About VHL / Von Hippel Lindau
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Images
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Popular VHL / Von Hippel Lindau Proteins
Source:
E. coli
Tag:
His, N-terminus
Source:
Wheat
Tag:
GST, N-terminus
Source:
Human
Tag:
Myc-DDK (Flag)
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/27/2024
Date Requested: 12/27/2024
