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UCHL1 / PGP9.5

ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase)

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Gene Name: ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase)
Family/Subfamily: Protease , Cysteine C12
Synonyms: UCHL1, Ubiquitin C-terminal hydrolase, PARK5, PGP9.5, PGP95, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Uch-L1, Ubiquitin carboxyl-terminal esterase L1, HEL-117, NDGOA, HEL-S-53, SPG79
Target Sequences: NM_004181 NP_004172.2 P09936

Publications (4)

1
Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system. Liu YA, Chen Y, Chiang AS, Peng SJ, Pasricha PJ, Tang SC. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2011 23:e446-57. (IHC) [PubMed:21895876]
2
Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. Zhang M, Deng Y, Luo Y, Zhang S, Zou H, Cai F, Wada K, Song W. Journal of neurochemistry. 2012 120:1129-38. [PubMed:22212137]
3
The fetal ovary exhibits temporal sensitivity to a 'real-life' mixture of environmental chemicals. Lea RG, Amezaga MR, Loup B, Mandon-Pépin B, Stefansdottir A, Filis P, Kyle C, Zhang Z, Allen C, Purdie L, Jouneau L, Cotinot C, Rhind SM, Sinclair KD, Fowler PA. Scientific reports. 2016 6:22279. (WB; Human) [Full Text Article] [PubMed:26931299] [PMC:PMC4773987] Related Antibodies: LS-B489.
4
Multifarious proteomic signatures and regional heterogeneity in glioblastomas. Park CK, Jung JH, Park SH, Jung HW, Cho BK. Journal of neuro-oncology. 2009 Aug;94:31-9. [Full Text Article] [PubMed:19219580] Related Antibodies: LS-B490.
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ELISA Kits (24)
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UCHL1 / PGP9.5 (24)
Human (8)
Mouse (5)
Rat (6)
Chicken (1)
Guinea pig (1)
Monkey (1)
Pig (1)
Porcine (1)
Rabbit (1)
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12 x 8-Well Microstrips (1)
96-Well Microplate (5)
96-Well Strip Plate (15)
Antibody Pair and Standard (3)
No (24)
Adherent Cell Cultures (1)
Cell Culture Supernatants (6)
Cell Lysates (6)
Plasma (10)
Serum (10)
Tissue Homogenates (8)
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
UCHL1 / PGP9.5 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.63 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Microplate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
UCHL1 / PGP9.5 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
UCHL1 / PGP9.5 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
UCHL1 / PGP9.5 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
UCHL1 / PGP9.5 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.82 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
UCHL1 / PGP9.5 ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,302; 1000 Wells/$1,947
UCHL1 / PGP9.5 ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,276; 1000 Wells/$1,903
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$792
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UCHL1 / PGP9.5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$730
UCHL1 / PGP9.5 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,356; 1000 Wells/$2,037
UCHL1 / PGP9.5 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
UCHL1 / PGP9.5 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
20.58 - 15000 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$911
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).