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UBC / Ubiquitin C

ubiquitin C

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Name: ubiquitin C
Synonyms: UBC, HUBCEP52, L40, HMG20, RPL40, Ubiquitin, Polyubiquitin-C, CEP52, Ubiquitin C
Target Sequences: M26880 AAA36789.1 P0CG48

Publications (5)

1
Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells. Arocena DG, Iwahashi CK, Won N, Beilina A, Ludwig AL, Tassone F, Schwartz PH, Hagerman PJ. Human molecular genetics. 2005 14:3661-71. [PubMed:16239243]
2
Protein composition of the intranuclear inclusions of FXTAS. Iwahashi CK, Yasui DH, An HJ, Greco CM, Tassone F, Nannen K, Babineau B, Lebrilla CB, Hagerman RJ, Hagerman PJ. Brain : a journal of neurology. 2006 129:256-71. [PubMed:16246864]
3
Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14. Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A. Cancer research. 2007 67:8682-9. [PubMed:17875708]
4
CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS. Hoem G, Raske CR, Garcia-Arocena D, Tassone F, Sanchez E, Ludwig AL, Iwahashi CK, Kumar M, Yang JE, Hagerman PJ. Human molecular genetics. 2011 20:2161-70. [PubMed:21389081] [PMC:PMC3090194]
5
Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG. The Journal of biological chemistry. 2012 287:2317-27. [PubMed:22069321] [PMC:PMC3268394] Related Antibodies: LS-B3386.
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☰ Filters
Antibodies (10)
ELISA Kits (6)
Primary (10)
Sandwich (6)
UBC / Ubiquitin C (16)
Human (11)
Mouse (5)
Rat (6)
Bovine (2)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
IHC (8)
IHC-P (3)
WB (8)
ELISA (2)
IF (4)
rabbit (8)
mouse (2)
Product Group
IHCPlus (2)
IgG (4)
IgG2a (2)
monoclonal mc (2)
polyclonal pc (8)
5B9.B3 (1)
96-Well Strip Plate (6)
Unconjugated (10)
aa1-32 (1)
aa36-66 (1)
No (15)
Yes (1)
Plasma (1)
Serum (1)
UBC / Ubiquitin C Antibody - Anti-UBC / Ubiquitin C antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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UBC / Ubiquitin C Rabbit anti-Human Polyclonal (aa1-32) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
UBC / Ubiquitin C Antibody - Anti-UBC / Ubiquitin C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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UBC / Ubiquitin C Rabbit anti-Human Polyclonal (aa36-66) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
UBC / Ubiquitin C Antibody - Immunofluorescent staining of aggresomes of mouse L-cells treated with lactacysteine.
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UBC / Ubiquitin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
0.05 ml/$386
Select
UBC / Ubiquitin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
UBC / Ubiquitin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Select
UBC / Ubiquitin C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
UBC / Ubiquitin C Antibody - 2% formaldehyde-fixed HeLa cells, 100X magnification.
Select
UBC / Ubiquitin C Mouse anti-Bovine Monoclonal (5B9.B3) Antibody
Mouse, Bovine, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$461
UBC / Ubiquitin C Antibody
Select
UBC / Ubiquitin C Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
UBC / Ubiquitin C Antibody - 2% formaldehyde-fixed HeLa cells, 100X magnification
Select
UBC / Ubiquitin C Mouse anti-Bovine Monoclonal Antibody
Mouse, Bovine, Rat, Human
IF, WB
Unconjugated
100 µg/$453
UBC / Ubiquitin C Antibody - Immunohistochemistry of paraffin-embedded Human duodenum using UBC Polycloanl Antibody at dilution of 1:100.
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UBC / Ubiquitin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439
UBC / Ubiquitin C Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using UBC Polycloanl Antibody at dilution of 1:100
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UBC / Ubiquitin C Rabbit anti-Rat Polyclonal Antibody
Rat, Human
IHC
Unconjugated
20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439
UBC / Ubiquitin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UBC / Ubiquitin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UBC / Ubiquitin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UBC / Ubiquitin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
UBC / Ubiquitin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
Viewing 1-16 of 16 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).