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TXN / Thioredoxin / TRX

thioredoxin

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Gene Name: thioredoxin
Synonyms: TXN, ADF, ATL-derived factor, SASP, Thioredoxin, TRX1, Thioredoxin delta 3, TRX, TXN delta 3, TRDX
Target Sequences: NM_003329 NP_003320.2 P10599

Publications (1)

1
Expression of genes and proteins of multidrug resistance in gastric cancer cells treated with resveratrol. Mieszala K, Rudewicz M, Gomulkiewicz A, Ratajczak-Wielgomas K, Grzegrzolka J, Dziegiel P, Borska S. Oncology letters. 2018 April;15:5825-5832. (Human) [Full Text Article] [PubMed:29552213] [PMC:PMC5840498]

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Antibodies (89)
Primary (89)
TXN / Thioredoxin / TRX (89)
Human (65)
Mouse (32)
Rat (27)
Bovine (1)
Chimpanzee (3)
Pig (1)
Rabbit (1)
IHC (14)
IHC-Fr (1)
IHC-P (7)
WB (81)
Flo (1)
ELISA (35)
ICC (3)
IF (2)
IP (7)
Peptide-ELISA (1)
rabbit (66)
mouse (23)
Product Group
IHCPlus (3)
IgG (38)
IgG1 (6)
IgG1,k (4)
IgG2a (2)
IgG2b,k (1)
monoclonal mc (26)
polyclonal pc (63)
002 (1)
092 (1)
1850CT339.14.1 (1)
1H6H6 (2)
2A7 (1)
2B1 (1)
2C9 (1)
2E3 (1)
GF1 (1)
APC (4)
APC Conjugated (5)
Azide-free (1)
Biotin Conjugated (9)
Cy3 Conjugated (4)
Cy7 Conjugated (4)
FITC Conjugated (9)
HRP Conjugated (7)
PE Conjugated (5)
Preservative Free (4)
Unconjugated (46)
aa1-105 (34)
aa1-30 (7)
C-Terminus (4)
aa 2-105 (1)
aa49-98 (1)
aa51-100 (1)
aa66-94 (1)
No (89)
TXN / Thioredoxin / TRX Antibody - Anti-Thioredoxin antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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TXN / Thioredoxin / TRX Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$565
TXN / Thioredoxin / TRX Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TXN / Thioredoxin / TRX Mouse anti-Human Monoclonal (2A7) Antibody
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
TXN / Thioredoxin / TRX Antibody - Immunohistochemistry of paraffin-embedded mouse lung tissue.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
TXN / Thioredoxin / TRX Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal (aa 2-105) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TXN / Thioredoxin / TRX Antibody - Western blot of Thioredoxin, mitochondrial antibody at 2 ug/ml. Lane 1:293T whole cell lysate. Lane 2: EC109 whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 18 kDa. Observed band size: 18 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
TXN / Thioredoxin / TRX Antibody - Western blot of Thioredoxin, mitochondrial antibody at 2 ug/ml. Lane 1:293T whole cell lysate. Lane 2: EC109 whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 18 kDa. Observed band size: 18 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
TXN / Thioredoxin / TRX Antibody - Western blot of Thioredoxin, mitochondrial antibody at 2 ug/ml. Lane 1:293T whole cell lysate. Lane 2: EC109 whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 18 kDa. Observed band size: 18 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
TXN / Thioredoxin / TRX Antibody - Anti-Txn rabbit monoclonal antibody at 1:500 dilution. Lane A: Hela Whole Cell Lysate. Lane B: A431 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 27 kDa. Observed band size: 27 kDa.
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TXN / Thioredoxin / TRX Rabbit anti-Mouse Monoclonal (Preservative Free) (002) Antibody
Mouse
ELISA, WB
Unconjugated, Preservative Free
100 µl/$412
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TXN / Thioredoxin / TRX Mouse Monoclonal Antibody
ELISA, WB
Unconjugated
100 µg/$842
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TXN / Thioredoxin / TRX Rabbit anti-Mouse Monoclonal (Preservative Free) (092) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
100 µl/$412
TXN / Thioredoxin / TRX Antibody - IHC analysis of Thioredoxin TRX using anti-Thioredoxin TRX antibody. Thioredoxin TRX was detected in paraffin-embedded section of mouse small intestine tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-Thioredoxin TRX Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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TXN / Thioredoxin / TRX Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, ICC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
TXN / Thioredoxin / TRX Antibody - IHC staining of FFPE mouse small intestine with TRX antibody at 1ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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TXN / Thioredoxin / TRX Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, ICC, IHC-P, WB
Unconjugated
100 µg/$575
TXN / Thioredoxin / TRX Antibody - Western blot of anti-TrX antibody in HL-60 cell line lysate. TrX(arrow) was detected using the purified antibody.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
WB
Unconjugated
400 µl/$393
TXN / Thioredoxin / TRX Antibody - TXN / Thioredoxin / TRX antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal (aa51-100) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
TXN / Thioredoxin / TRX Antibody - Anti-TXN rabbit polyclonal antibody at 1:500 dilution. Lane A: HL60 Whole Cell Lysate. Lane B: Hela Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 12 kDa. Observed band size: 12 kDa.
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TXN / Thioredoxin / TRX Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
ELISA, ICC, IF, WB
Unconjugated, Preservative Free
100 µl/$412
TXN / Thioredoxin / TRX Antibody - Western blot of recombinant TXN / Thioredoxin / TRX.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TXN / Thioredoxin / TRX Mouse anti-Human Monoclonal (aa1-105) (Biotin) Antibody
Human
WB
Biotin Conjugated
200 µl/$358
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TXN / Thioredoxin / TRX Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$562
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TXN / Thioredoxin / TRX Mouse anti-Human Monoclonal (2B1) Antibody
Human
ELISA, Flo, IHC-Fr, IHC-P, WB
Unconjugated
0.2 mg/$565
TXN / Thioredoxin / TRX Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using TXN Polyclonal Antibody at dilution of 1:40.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TXN / Thioredoxin / TRX Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using TXN Polyclonal Antibody at dilution of 1:40.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TXN / Thioredoxin / TRX Antibody - Immunohistochemistry of paraffin-embedded Rat lung using TXN Polyclonal Antibody at dilution of 1:100 (40x lens).
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
Select
TXN / Thioredoxin / TRX Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
40 µg/$488
TXN / Thioredoxin / TRX Antibody - Western blot analysis of extracts of various cell lines, using TXN antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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TXN / Thioredoxin / TRX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TXN / Thioredoxin / TRX Antibody
Select
TXN / Thioredoxin / TRX Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).