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TRPM8
transient receptor potential cation channel, subfamily M, member 8
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
| Gene Name: | transient receptor potential cation channel, subfamily M, member 8 |
| Family/Subfamily: | Ion Channel , Calcium channel - TRP |
| Synonyms: | TRPM8, CMR1, Cold-menthol receptor type 1, LTrpC-6, TRPP8, Trp-p8, LTRPC6 |
| Target Sequences: | NM_024080 NP_076985.4 Q7Z2W7 |
Publications (4)
1
Characterization of the decision network for wing expansion in Drosophila using targeted expression of the TRPM8 channel. Peabody NC, Pohl JB, Diao F, Vreede AP, Sandstrom DJ, Wang H, Zelensky PK, White BH. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:3343-53.
[PubMed:19295141]
[PMC:PMC2717795]
2
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. Ma S, Yu H, Zhao Z, Luo Z, Chen J, Ni Y, Jin R, Ma L, Wang P, Zhu Z, Li L, Zhong J, Liu D, Nilius B, Zhu Z. Journal of molecular cell biology. 2012 4:88-96.
[PubMed:22241835]
3
Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2. Winking M, Hoffmann DC, Khn C, Hilgers RD, Lckhoff A, Khn FJ. PloS one. 2012 7:e49877.
[PubMed:23185472]
[PMC:PMC3503820]
Related Antibodies: LS-C160235.
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TRPM8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Dog, Guinea pig, Hamster, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Neuroscience
Fast Shipping
TRPM8 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Horse, Bat, Human
IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
TRPM8 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TRPM8 Rabbit anti-Human Polyclonal (aa251-300) (HRP) Antibody
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TRPM8 Rabbit anti-Human Polyclonal (aa251-300) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TRPM8 Rabbit anti-Human Polyclonal (aa251-300) (FITC) Antibody
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TRPM8 Rabbit anti-Human Polyclonal (aa263-292) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Neuroscience
TRPM8 Rabbit anti-Human Polyclonal (aa278-292) Antibody
Drosophila, Mouse, Human
IHC, IHC-P
Unconjugated
50 µl/$460
Neuroscience
Fast Shipping
TRPM8 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Guinea pig, Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
TRPM8 Rabbit anti-Human Polyclonal (aa69-98) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TRPM8 Rabbit anti-Human Polyclonal (aa250-300) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
TRPM8 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
TRPM8 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
TRPM8 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
TRPM8 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
TRPM8 Rabbit anti-Human Polyclonal (aa521-552) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TRPM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
TRPM8 Rabbit anti-Human Polyclonal (aa1075-1104) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TRPM8 Rabbit anti-Human Polyclonal (aa926-956) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TRPM8 Rabbit anti-Human Polyclonal (aa900-950) Antibody
Human
IHC, WB
Unconjugated
500 µg/$393
TRPM8 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
TRPM8 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TRPM8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
TRPM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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