TRPM8 is a transmembrane ion channel protein that is activated by cooling and is involved in menthol and cold sensation. Loss of TRPM8 in mice results in changes in response behaviors to cold temperatures such as decreased cold avoidance. In prostate cancer cells, TRPM8 is highly expressed and is involved in cancer cell growth, survival and regulation of calcium levels in androgen-dependent cancers, making it a potential target of therapy. In immunohistochemistry of normal tissue, it has plasma membrane positivity in the prostate and liver, with localization in the endoplasmic reticulum in prostate cancer cells. References: CRC Press/Taylor & Francis; 2007. Chapter 13. Frontiers in Neuroscience. PMID: 21204488; Neuron. 2007 May 3;54(3):371-8; Cancer Res. 2004 Nov 15;64(22):8365-73, PMID: 15548706; The UniProt Consortium. Nucleic Acids Research. 2019. 47 (D1): D506–D515, DOI: 10.1093/nar/gky1049;