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TRIM28 / KAP1

tripartite motif containing 28

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

Gene Name: tripartite motif containing 28
Family/Subfamily: Tripartite Motif , TIF1
Synonyms: TRIM28, E3 SUMO-protein ligase TRIM28, KRIP-1, Nuclear corepressor KAP-1, KAP-1, KAP1, KRAB-interacting protein 1, TIF1B, RNF96, TIF1-beta, TIF1beta, Tripartite motif-containing 28, KRAB-associated protein 1, RING finger protein 96, TF1B, Tif1beta zinc finger protein, Tripartite motif containing 28
Target Sequences: NM_005762 NP_005753.1 Q13263

Publications (1)

1
Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis. Mark A Gillespie, Carmen G Palii, Daniel Sanchez-Taltavull, Paul Shannon, William J R Longabaugh, Damien J Downes, Karthi Sivaraman, Herbert M Espinoza, Jim R Hughes, Nathan D Price, Theodore J Perkins, Jeffrey A Ranish, Marjorie Brand. Molecular cell. 2020 June;78:960-974.e11. [Full Text Article] [PubMed:32330456] [PMC:PMC7344268] Related Antibodies: LS-C287177.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
TRIM28 / KAP1 (8)
No (8)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (2)
Myc-DDK (Flag) (3)
Human (6)
Mouse (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
TRIM28 / KAP1 Protein - Purified recombinant protein TRIM28 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
88.4 kDa
20 µg/$1,107
TRIM28 / KAP1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
TRIM28 / KAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
88.4 kDa
100 µg/$494
TRIM28 / KAP1 Protein - Recombinant Transcriptional Intermediary Factor 1 Beta (TIF1b) by SDS-PAGE
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E. coli
His, N-Terminal
33.1kDa
10 µg/$243; 50 µg/$291; 200 µg/$402; 100 µg/$339; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298
TRIM28 / KAP1 Protein - Recombinant Transcriptional Intermediary Factor 1 Beta (TIF1b) by SDS-PAGE
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E. coli
His, N-Terminal
37.1kDa
10 µg/$247; 50 µg/$303; 200 µg/$462; 100 µg/$370; 1 mg/$1,284; 500 µg/$922; 5 mg/$2,151; 2 mg/$1,437
TRIM28 / KAP1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TRIM28 / KAP1 Protein - 12.5% SDS-PAGE of human TRIM28 stained with Coomassie Blue
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Wheat Germ Extract
GST
114.9 kDa
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
88.4 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).