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TREM2 / TREM-2
triggering receptor expressed on myeloid cells 2
TREM2 / TREM-2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | triggering receptor expressed on myeloid cells 2 |
| Synonyms: | TREM2, Trem2b, TREM-2, Trem2a, Trem2c |
| Target Sequences: | NM_018965 NP_061838.1 Q9NZC2 |
Publications (3)
1
Dark microglia: A new phenotype predominantly associated with pathological states. Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ. Glia. 2016 64:826-39. (IHC; Mouse)
[Full Text Article]
[PubMed:26847266]
[PMC:PMC4949554]
2
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. Gonçalves LA, Rodrigues-Duarte L, Rodo J, Vieira de Moraes L, Marques I, Penha-Gonçalves C. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:19531-6. (WB; Mouse)
[Full Text Article]
[PubMed:24218563]
Related Antibodies: LS-C272143.
3
microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. Bhattacharjee S, Zhao Y, Dua P, Rogaev EI, Lukiw WJ. PloS one. 2016 March;11:e0150211. [Full Text Article]
[PubMed:26949937]
[PMC:PMC4780721]
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TREM2 / TREM-2 Mouse anti-Human Monoclonal (Preservative Free) (08) Antibody
Human
ELISA, IHC-P
Unconjugated, Preservative Free
50 µl/$460
TREM2 / TREM-2 Goat anti-Human Polyclonal (aa199-212) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
TREM2 / TREM-2 Rat anti-Mouse Monoclonal (GF1) Antibody
Mouse
ELISA, Flo, IP
Unconjugated
100 µg/$826
TREM2 / TREM-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
TREM2 / TREM-2 Mouse anti-Human Monoclonal (aa19-161) (2B5) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
TREM2 / TREM-2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC-P
Unconjugated
100 µl/$412
TREM2 / TREM-2 Rat anti-Mouse Monoclonal (78.18) Antibody
Mouse
Flo
Unconjugated
0.1 mg/$410; 0.25 mg/$499
TREM2 / TREM-2 Rat anti-Mouse Monoclonal (RPE) (78.18) Antibody
Mouse
Flo
RPE Conjugated
100 Tests/$522
TREM2 / TREM-2 Rat anti-Mouse Monoclonal (Low Endotoxin) (78.18) Antibody
Mouse
Flo
Unconjugated, Low Endotoxin
0.5 mg/$671
TREM2 / TREM-2 Rabbit anti-Mouse Polyclonal (aa22-48) Antibody
Mouse
WB
Unconjugated
400 µl/$393
TREM2 / TREM-2 Rabbit anti-Human Polyclonal (aa143-192) Antibody
Human
WB
Unconjugated
100 µl/$424
TREM2 / TREM-2 Rabbit anti-Rat Polyclonal (aa1-228) Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
TREM2 / TREM-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
E. coli
His-GST
54.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Mammalian Cells
6His, N-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
TREM2 / TREM-2 Rabbit anti-Mouse Monoclonal (aa1-168) (Preservative Free) (014) Antibody
Mouse
ELISA, ICC, IF
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
TREM2 / TREM-2 Rabbit anti-Mouse Polyclonal (aa22-48) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
TREM2 / TREM-2 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
TREM2 / TREM-2 Rabbit anti-Human Monoclonal (Preservative Free) (016) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
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