Mouse TREM2 / TREM-2

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

78.18

Unconjugated. Also available conjugated with RPE.

Protein G purified

Unmodified. Also available Low Endotoxin.

Mouse TREM-2 Fc fusion protein.

Recognizes Triggering receptor expressed on myeloid cells 2 (TREM-2), an activating receptor of the Ig superfamily. TREM-2 forms a receptor signalling complex with DAP12 to trigger the activation of the immune response in macrophages and dendritic cells. It may be involved in chronic inflammation and may promote the production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 may also have a functional role in osteoclast formation. Stimulation of TREM-2 with clone 78.18 enhances multinucleated osteoclast formation in vitro. Clone 78.18 may also be used to block TREM-2 on pre-osteoclasts to inhibit the formation of multinuclear osteoclasts and to inhibit bone resorption by mature osteoclasts.

• Flow Cytometry (1:25 - 1:200)

PBS, 0.09% Sodium Azide

Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9NZC2 NCBI: NM_018965 NP_061838.1