TP53 / p53

tumor protein p53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

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Products

Proteins (26)

Type

Over-Expression Lysate (8)

Recombinant (18)

Target

TP53 / p53 (26)

Publications

No (26)

Tag

6His, N-terminus (2)

DDK,C-terminus (1)

GST (2)

GST, N-terminus (1)

GST-His, N-terminus (1)

His (2)

His, N-Terminal (2)

His-GST (1)

His-SUMO (2)

Myc-DDK (Flag) (11)

Myc-DDK (Flag), C-terminus (1)

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Species

Human (18)

Mouse (2)

Rat (2)

Source

293T Cells (4)

E. coli (9)

HEK 293 Cells (8)

Sf9 Cells (1)

Wheat Germ Extract (3)

Yeast (1)

Purification

Purified (6)

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Human TP53 / p53 Protein (Recombinant His, N-Terminal) (Gly108-Lys370) - LS-G13175

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.4 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

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Mouse TP53 / p53 Protein (Recombinant His-SUMO) (Full Length) - LS-G21279

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

59.1 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human TP53 / p53 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G26547

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

46.3 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human TP53 / p53 Protein (Recombinant 6His, N-terminus) (aa1-393) - LS-G57274

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Mouse TP53 / p53 Protein (Recombinant His) (aa137-390) - LS-G13168

Source:

E. coli

Tag:

His

Molecular Weight:

30.3 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Human TP53 / p53 Protein (Recombinant His-SUMO) (Full Length) - LS-G21278

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

59.49 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Rat TP53 / p53 Protein (Recombinant His) (Full Length) - LS-G22669

Source:

E. coli

Tag:

His

Molecular Weight:

47.5 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat TP53 / p53 Protein (Recombinant His, N-Terminal) (Pro90-Ala354) - LS-G13174

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.8 kDa

Price:

50 µg/$482; 10 µg/$287; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human TP53 / p53 Protein (Recombinant GST) (Full Length) - LS-G30747

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.97 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TP53 / p53 Protein (Recombinant GST) (Full Length) - LS-G30748

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.86 kDa

Price:

2 µg/$439

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Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85433

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$150

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Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85434

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

20 µg/$150

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Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85435

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.3 kDa

Price:

20 µg/$150

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Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85436

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

20 µg/$150

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Human TP53 / p53 Protein (Recombinant GST, N-terminus) (aa94-201) - LS-G60400

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99072

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

100 µg/$494

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Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69732

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$1,107

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Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69733

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$1,107

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Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69734

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

20 µg/$1,107

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TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124513

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

100 µg/$494

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TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124515

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.3 kDa

Price:

100 µg/$494

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TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124516

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

100 µg/$494

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Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142297

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

43.6 kDa

Price:

20 µg/$1,107

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Human TP53 / p53 Protein (Recombinant DDK,C-terminus) - LS-G142327

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

44 kDa

Price:

20 µg/$677

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Human TP53 / p53 Protein (Recombinant GST-His, N-terminus) - LS-G143845

Source:

E. coli

Tag:

GST-His, N-terminus

Molecular Weight:

72.5 kDa

Price:

50 µg/$419

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