TP53 / p53

tumor protein p53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

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Products

ELISA Kits (55)

Type

Cell-Based (1)

Cell-Based Phosphorylation (11)

Competitive EIA (1)

Custom (6)

Development Kit (2)

DNA Binding (1)

DNA Binding Phosphorylation (7)

Sandwich (22)

Sandwich CLIA (4)

Target

TP53 / p53 (55)

Reactivity

Human (32)

Mouse (18)

Rat (15)

Chicken (2)

Dog (1)

Guinea pig (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Product Group

DevKit DuoPlus (2)

Format

12 x 8-Well Microstrips (10)

96-Well Microplate (17)

96-Well Strip Plate (26)

Antibody Pair and Standard (2)

Publications

No (55)

Sample Type

Adherent Cell Cultures (12)

Cell Culture Supernatants (4)

Cell Lysates (13)

Nuclear Lysates (8)

Plasma (23)

Serum (23)

Tissue Homogenates (8)

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Rat TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F12244

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse/Human/Rat Phospho-TP53 / p53 (Ser20) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1196

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-TP53 / p53 (Thr18) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1596

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human TP53 / p53 (DNA-Binding ELISA) ELISA Kit - LS-F842

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Chicken TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F48870

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F4114

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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Human TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F23980

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse/Human/Rat Phospho-TP53 / p53 (Ser20) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F929

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

Select

Human TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F174

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.328 - 32 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$635

Select

Mouse/Human/Rat TP53 / p53 (Cell-Based ELISA) ELISA Kit - LS-F2210

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

Select

Human TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F2741

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates

Price:

1 Plate/$699

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Pig TP53 / p53 (Custom ELISA) ELISA Kit - LS-F15418

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Dog TP53 / p53 (Custom ELISA) ELISA Kit - LS-F15419

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse TP53 / p53 (Custom ELISA) ELISA Kit - LS-F15424

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Chicken TP53 / p53 (Custom ELISA) ELISA Kit - LS-F15420

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Bovine TP53 / p53 (Custom ELISA) ELISA Kit - LS-F15421

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Human TP53 / p53 (Custom ELISA) ELISA Kit - LS-F15422

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

Select

Human TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F35123

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat TP53 / p53 (CLIA) ELISA Kit - LS-F37764

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human TP53 / p53 (CLIA) ELISA Kit - LS-F29634

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Rat TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F36193

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse TP53 / p53 (Sandwich ELISA) ELISA Kit - LS-F36194

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse TP53 / p53 (CLIA) ELISA Kit - LS-F31008

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

DevKit DuoPlus Mouse TP53 / p53 ELISA Development Kit - LS-F71709

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

12.5 - 800 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

500 Wells/$1,207; 1000 Wells/$1,787

Select

DevKit DuoPlus Human TP53 / p53 ELISA Development Kit - LS-F71615

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,182; 1000 Wells/$1,747

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