Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
TNFSF10 / TRAIL
tumor necrosis factor (ligand) superfamily, member 10
TNFSF10 / TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 10 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF10, Apo-2L, APO2L, Apo-2 ligand, CD253, CD253 antigen, TRAIL, Protein TRAIL, TL2 |
| Target Sequences: | NM_003810 NP_003801.1 P50591 |
Publications (2)
1
IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. Herzer K, Hofmann TG, Teufel A, Schimanski CC, Moehler M, Kanzler S, Schulze-Bergkamen H, Galle PR. Cancer research. 2009 69:855-62.
[PubMed:19141642]
2
TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration. Liya Qin, Jian Zou, Alexandra Barnett, Ryan P Vetreno, Fulton T Crews, Leon G Coleman Jr. International journal of molecular sciences. 2021 March;22:2547. [Full Text Article]
[PubMed:33806288]
[PMC:PMC7961445]
☰ Filters
Products
Antibodies
(123)
ELISA Kits
(33)
Proteins
(28)
Type
Cell-Based
(1)
Custom
(1)
Development Kit
(3)
Over-Expression Lysate
(2)
Primary
(123)
Recombinant
(26)
Sandwich
(24)
Sandwich CLIA
(4)
Target
TNFSF10 / TRAIL
(184)
Reactivity
Human
(118)
Mouse
(34)
Rat
(21)
Chicken
(1)
Dog
(12)
Monkey
(2)
Pig
(3)
Porcine
(1)
Rabbit
(1)
Application
IHC
(17)
IHC-Fr
(1)
IHC-P
(6)
WB
(95)
Flo
(14)
ELISA
(31)
Func
(4)
ICC
(2)
IF
(8)
IP
(1)
Peptide-ELISA
(2)
Host
rabbit
(80)
mouse
(38)
rat
(5)
Product Group
DevKit Core
(1)
DevKit DuoPlus
(2)
IHCPlus
(3)
Isotype
IgG
(43)
IgG1
(11)
IgG1,k
(8)
IgG2a
(8)
IgG2b
(4)
Clonality
monoclonal mc
(43)
polyclonal pc
(80)
Clone
101
(1)
2E5
(5)
366G/76/3
(1)
55B709.3
(1)
HS501
(1)
OTI12E12
(1)
OTI2C12
(1)
OTI6B5
(1)
OTI9A8
(1)
RIK-2
(2)
SB91a
(2)
SB91c
(1)
Format
1000 Wells
(1)
12 x 8-Well Microstrips
(4)
96-Well Microplate
(7)
96-Well Strip Plate
(19)
Antibody Pair and Standard
(2)
APC
(5)
APC Conjugated
(7)
Biotin Conjugated
(14)
Cy3 Conjugated
(5)
Cy7 Conjugated
(5)
FITC Conjugated
(11)
HRP Conjugated
(10)
Low Endotoxin
(2)
PE Conjugated
(9)
Preservative Free
(1)
Unconjugated
(62)
Epitope
aa114-281
(18)
aa115-287
(8)
aa36-281
(8)
aa40-291
(8)
aa39-281
(4)
aa56-105
(4)
aa95-281
(3)
aa17-35
(2)
1-80 aa, Internal
(1)
C-Terminus
(1)
C-terminal
(1)
Internal
(1)
Ser63
(1)
aa 39-281
(1)
aa261-277
(1)
aa31-80
(1)
Publications
No
(183)
Yes
(1)
Sample Type
Adherent Cell Cultures
(1)
Cell Culture Supernatants
(10)
Cell Lysates
(10)
Cerebrospinal Fluid
(1)
Plasma
(24)
Saliva
(1)
Serum
(24)
Tissue Homogenates
(12)
Urine
(1)
Tag
6His, C-terminus
(2)
DDK (Flag)
(1)
GST
(1)
His
(2)
His, N-Terminal
(1)
His-GST, N-terminus
(1)
His-Linker Peptide
(3)
His-S
(1)
His-T7
(1)
Isoleucine Zipper Motif
(1)
Myc-DDK (Flag)
(2)
Species
Dog
(1)
Human
(21)
Mouse
(4)
Rat
(1)
Source
293T Cells
(1)
E. coli
(24)
HEK 293 Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(13)
Low Endotoxin Level
Low endotoxin level
(17)
Biologically Active
Biologically active
(7)
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (1-80 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TNFSF10 / TRAIL Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
TNFSF10 / TRAIL Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
500 µg/$533
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
100 µl/$763
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa114-281) Antibody
Human
WB
Unconjugated
100 µl/$292; 200 µl/$327; 500 µl/$443; 1 ml/$501; 2 ml/$626; 5 ml/$1,072
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa95-281) (366G/76/3) Antibody
Human
Flo, WB
Unconjugated
100 µg/$860; 500 µg/$1,223
Sandwich
12 x 8-Well Microstrips
Human
32 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$414
E. coli
His-GST, N-terminus
52.0 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
E. coli
Isoleucine Zipper Motif
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
28kDa-82kDa
10 µg/$337
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (aa31-80) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (C-terminal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
TNFSF10 / TRAIL Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$629
Sandwich
96-Well Microplate
Mouse
2 - 600 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
E. coli
His
32.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa95-281) (Low Endotoxin) (2E5) Antibody
Human
Flo, WB
Unconjugated, Low Endotoxin
0.5 mg/$869
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (aa 39-281) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TNFSF10 / TRAIL Rat anti-Mouse Monoclonal Antibody
Mouse
Flo
Unconjugated
100 µg/$587
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (RIK-2) Antibody
Human
Flo
Unconjugated
100 µg/$292
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa17-35) (55B709.3) Antibody
Human
WB
Unconjugated
0.1 mg/$386
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
20.0 kDa
10 µg/$268; 50 µg/$349
Viewing 1-25
of 184
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
