Recombinant Protein

TNFSF10 / TRAIL

Human

Unmodified

28kDa-82kDa

E. coli

E. coli

Greater than 95% by SDS-PAGE

Induces apoptosis in vitro in different human cancer cell lines with an EC50 of 5-200ng/ml, depending on the individual cell line used. Recombinant izTRAIL does not kill 4-day cultures of primary human hepatocytes (PHH) at concentrations of at least up to 1µg/ml (Ganten 2006). Good bioavailability in vivo, shows no toxic effects in mice at doses of at least up to 500µg per day (Wissink 2006).

Less than 0.01 EU/µg protein (determined by LAL method).

Lyophilized from 20 mM Tris-Cl, 0.5 M Arginine-HCl, 100 mM NaCl, 0.02% Tween20

Reconstitute with 100 µl sterile water.

Store lyophilized at -20°C for up to 6 months. Once reconstituted store at 4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This protein carries the LSBio 100% Guarantee.

Uniprot: P50591 NCBI: NM_003810 NP_003801.1