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TNFRSF17 / BCMA is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Gene Name: | tumor necrosis factor receptor superfamily, member 17 |
Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
Synonyms: | TNFRSF17, B cell maturation antigen, BCMA, CD269 antigen, B-cell maturation factor, B-cell maturation protein, BCM, CD269 |
Target Sequences: | NM_001192 NP_001183.2 Q02223 |
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