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TNF Alpha

tumor necrosis factor

TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Gene Name:	tumor necrosis factor
Family/Subfamily:	TNF , not assigned-TNF
Synonyms:	TNF, APC1 protein, Cachectin, DIF, TNF Alpha, Tumor necrosis factor-alpha, TNF-alpha, TNF-a, TNFA, Tumor necrosis factor, TNF, macrophage-derived, TNF, monocyte-derived, TNFSF2
Target Sequences:	NM_000594 NP_000585.2 P01375

Publications (20)

Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells. Ivanov VN, Ronai Z. The Journal of biological chemistry. 1999 274:14079-89. [PubMed:10318823] Related Antibodies: LS-C41024.

TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57. [PubMed:17641010] Related Antibodies: LS-C41025.

Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:3885-90. [PubMed:22355106] [PMC:PMC3309713] Related Antibodies: LS-C41024.

Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide. Qu X, Pröll M, Neuhoff C, Zhang R, Cinar MU, Hossain MM, Tesfaye D, Große-Brinkhaus C, Salilew-Wondim D, Tholen E, Looft C, Hölker M, Schellander K, Uddin MJ. PloS one. 2015 10:e0121574. (WB; Bovine) [Full Text Article] [PubMed:25793534] [PMC:PMC4368608] Related Antibodies: LS-C43037.

Supervised Clustering of Adipokines and Hormonal Receptors Predict Prognosis in a Population of Obese Women with Type 1 Endometrial Cancer. Uzan J, Laas E, Alsamad IA, Skalli D, Mansouri D, Haddad B, Touboul C. International journal of molecular sciences. 2017 18: (WB; Human) [Full Text Article] [PubMed:28505082] [PMC:PMC5454967]

The Potential of Asiatic Acid in the Reversion of Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats. Andrzej Wróbel, Lukasz Zapala, Tomasz Kluz, Artur Rogowski, Marcin Misiek, Kajetan Juszczak, Jacek Sienko, Daniela Gold, Klaudia Stangel-Wójcikiewicz, Ewa Poleszak, Piotr Radziszewski. International journal of molecular sciences. 2021 May;22: [Full Text Article] [PubMed:34072606] [PMC:PMC8198845]

CD4 T-cell immune stimulation of HER2?+?breast cancer cells alters response to trastuzumab in vitro. Patrick N Song, Ameer Mansur, Kari J Dugger, Tessa R Davis, Grant Howard, Thomas E Yankeelov, Anna G Sorace. Cancer cell international. 2020 November;20:544. [Full Text Article] [PubMed:33292267] [PMC:PMC7654187]

O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to Corticosterone Treatment. Andrzej Wróbel, Anna Serefko, Aleksandra Szopa, Daniela Ulrich, Ewa Poleszak, Tomasz Rechberger. Frontiers in pharmacology. 2020 August;11:1002. [Full Text Article] [PubMed:32733244] [PMC:PMC7360849]

Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi Xu. Frontiers in cell and developmental biology. 2020 August;8:608. [Full Text Article] [PubMed:32733897] [PMC:PMC7363772]

Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease. Yan-Fang Xian, Chang Qu, Yue Liu, Siu-Po Ip, Qiu-Ju Yuan, Wen Yang, Zhi-Xiu Lin. Oxidative medicine and cellular longevity. 2020 July;2020:5920476. [PubMed:32714487] [PMC:PMC7354664]

Effects of arginase inhibition via jugular infusion of N?-hydroxy-nor-l-arginine on metabolic and immune indices in lactating dairy cows. L Y Ding, Y F Wang, Y Z Shen, G Zhou, X Zhang, M Z Wang, J J Loor, J Zhang. Journal of dairy science. 2019 Apr;102:3310-3320. [Full Text Article] [PubMed:30738683]

Inhibition of lncRNA H19/miR-370-3p pathway mitigates neuronal apoptosis in an in vitro model of spinal cord injury (SCI). Xin Li, Yan Qian, Kaihua Tang, Yang Li, Rui Tao, Chunyan Gong, Li Huang, Kaiwen Zou, Lindong Liu. Translational neuroscience. 2021 Mar;12:103-113. [Full Text Article] [PubMed:33708438] [PMC:PMC7925972] Related Antibodies: LS-B6067.

Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013] Related Antibodies: LS-C18838.

Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]

Carbocisteine as a Modulator of Nrf2/HO-1 and NF?B Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis. Amir Mohamed Abdelhamid, Mahmoud E Youssef, Simona Cavalu, Gomaa Mostafa-Hedeab, Amal Youssef, Sara T Elazab, Samar Ibrahim, Shady Allam, Rehab Mohamed Elgharabawy, Eman El-Ahwany, Noha A Amin, Ahmed Shata, Osama A Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Ahmed Alhowail, Gaber El-Saber Batiha, Engy A El-Mahmoudy, Maram Attia, Alaa Allam, Mona Y Zaater, Mona M Osman, Manar Nader, Aya Taha, Nada Abul Makarem, Sameh Saber. Frontiers in pharmacology. 2022 June;13:887233. [Full Text Article] [PubMed:35754464] [PMC:PMC9214041]

Immunohistochemical Inflammation in Histologically Normal Appendices in Patients with Right Iliac Fossa Pain. Emmanouil Psaltis, Abed M Zaitoun, Keith R Neal, Dileep N Lobo. World journal of surgery. 2021 December;45:3592-3602. [Full Text Article] [PubMed:34392384] [PMC:PMC8572837] Related Antibodies: LS-B7268.

Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]

Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions. Nancy S Younis, Maged E Mohamed, Nermin A El Semary. Marine drugs. 2022 January;20:56. [Full Text Article] [PubMed:35049911] [PMC:PMC8781738]

Cellular and mitochondrial adaptation mechanisms in the colon of lactating dairy cows during hyperthermia. Mehdi Eslamizad, Dirk Albrecht, Björn Kuhla, Franziska Koch. Journal of dairy science. 2023 December; [Full Text Article] [PubMed:38056565]

Proteome of the early embryo-maternal dialogue in the cattle uterus. Mu[Character f1]oz M, Corrales FJ, Caama[Character f1]o JN, D[Character ed]ez C, Trigal B, Mora MI, Mart[Character ed]n D, Carrocera S, G[Character f3]mez E. Journal of proteome research. 2012 Feb;11:751-66. [Full Text Article] [PubMed:22148898] Related Antibodies: LS-C43037.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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